NCT07354074

Who might be able to join this trial:

• You must be willing and able to sign a consent form before joining the study (for children, a parent or guardian will do this)
• You must be aged 1 year old up to (but not including) 18 years old when you enroll
• You must have been diagnosed with a specific type of leukemia called CML in chronic phase (an early, more stable stage), confirmed by a specific lab test showing a chromosome change called the Philadelphia chromosome
• You were either newly diagnosed with this condition within the last 3 months, OR your current or previous leukemia medication (called a TKI) is not working well enough or is causing serious side effects — this includes situations where lab results show the leukemia is not responding as expected at certain checkpoints (3, 6, or 12 months), or where the leukemia has started becoming resistant to treatment
• A specific lab test done at screening must detect a particular form of the leukemia gene (BCR::ABL1) that can be accurately measured with a standard test
• You must be well enough to carry out some daily activities, measured by a standard health score (confirm with trial site)

Who may not be able to join:

• You have returned to the early/stable phase of CML after it had previously progressed to a more advanced stage
• You have already had a stem cell transplant (a procedure using donor blood stem cells)
• You are currently planned to have a stem cell transplant
• Lab tests show your leukemia has a specific genetic change that is already known to make it resistant to the medication being studied in this trial

Important: Always verify eligibility with the trial site directly before applying.