NCT07247370

Who might be able to join this trial:

• You have been diagnosed with moderate to severe alcohol use disorder (AUD) based on standard psychiatric guidelines (DSM-5)
• You currently have a diagnosis of Major Depressive Disorder (MDD) based on standard psychiatric guidelines (DSM-5)
• You are motivated to cut down or stop drinking alcohol
• In the month before screening, you drank at least 21 standard drinks per week, or had at least 2 days per week where you drank heavily (5 or more drinks in a day for men; 4 or more for women)
• You are between 18 and 70 years old
• You have sufficient thinking and English language skills to understand and consent to the study and take part in interviews
• You have a stable place to live
• You are willing to sign a consent form agreeing to take part
• You are willing to follow the study procedures and attend all required appointments

Who may not be able to join:

• You have been diagnosed, now or in the past, with a psychotic disorder, bipolar I disorder, or a psychosis caused by substance use
• You are currently at high risk of suicide, or have made a suicide attempt in the past 6 months
• You have been diagnosed, now or in the past, with moderate to severe misuse of ketamine or similar dissociative drugs
• You have used ketamine (whether prescribed or not) in the past 4 weeks
• You are already taking part in another clinical trial that could affect your safety or the results of this study
• You are pregnant, breastfeeding, or planning to become pregnant during the study
• You have serious uncontrolled health conditions, such as poorly controlled high blood pressure, severe heart disease, a history of stroke or brain injury, or severe liver, bladder, or kidney disease (confirm with trial site)
• You are showing significant signs of alcohol withdrawal at the time of screening
• You have a history of raised pressure in the brain, seizures, or an epilepsy diagnosis (except for fever-related seizures in childhood)
• You have a known allergy or sensitivity to ketamine or its ingredients
• You are currently taking psychiatric medications, unless you have been on a stable dose of antidepressants for at least 4 weeks
• You have a current moderate or severe addiction to substances other than nicotine or caffeine (although stable opioid use disorder on maintenance treatment may be permitted — confirm with trial site)
• The study doctor decides that, for any reason, taking part would not be safe for you or could affect the study results

Important: Always verify eligibility with the trial site directly before applying.