NCT06819007

Who might be able to join this trial:

• You must be willing to sign consent forms before any trial-related procedures begin, including consent for optional genetic testing.
• You must be 18 years of age or older at the time of signing the consent form.
• You have been diagnosed with a specific type of ovarian, fallopian tube, or primary peritoneal cancer (a high-grade epithelial type, confirmed by tissue testing), including types such as serous, endometrioid, clear cell, carcinosarcoma, or mucinous.
• You have been newly diagnosed with an advanced stage of the disease (Stage III or IV).
• Your cancer must show a certain level of a protein called HER2, confirmed through a specific type of tissue test sent to a central laboratory.
• You must have enough tumor tissue available (a tissue block or slides) for laboratory testing, including HER2 testing and other analysis.
• You must have an available local test result for HRD (a measure of DNA repair in cancer cells) or BRCA gene status.
• You have already received up to 6 cycles of standard chemotherapy (platinum-based) combined with a drug called bevacizumab, and your doctor considers you suitable to continue with bevacizumab alone as a maintenance treatment.

Who may not be able to join:

• Your ovarian, fallopian tube, or peritoneal cancer is not of the epithelial type (confirm with trial site).
• You have a known harmful change in the BRCA gene that would make you eligible for a type of drug called a PARP inhibitor.
• Your doctor has determined that you should receive a PARP inhibitor as part of your standard maintenance treatment.
• You have had a serious allergic reaction to any of the drugs used in this trial or to similar types of medications (monoclonal antibodies).
• You have had a stroke, mini-stroke (TIA), or a type of brain bleed (subarachnoid hemorrhage) within the 6 months before joining the trial.
• You have a condition where your blood does not clot properly (and you are not on blood-thinning medication).
• You have a history of abnormal bleeding, an abnormal opening in the bowel or abdomen (fistula or perforation), or active bleeding in the digestive system within the past 6 months.
• You currently have a blockage in your bowel.
• You have had a heart attack within the past 6 months, or you have moderate-to-severe heart failure symptoms.
• Your heart's electrical activity (measured by an ECG test) shows a specific abnormality called a prolonged QT interval above a certain level.
• You have a history of a lung condition called interstitial lung disease (ILD) or pneumonitis that needed steroid treatment, or you currently have this condition, or it cannot be ruled out based on your scans.

Important: Always verify eligibility with the trial site directly before applying.