NCT06732180

Who might be able to join this trial:

• You are willing and able to give written consent and follow the study's rules and requirements
• You are between 30 and 85 years old (any sex)
• You have been diagnosed with Parkinson's disease (PD) according to recognised medical guidelines
• Your Parkinson's diagnosis was made within the last 7 years
• Your body weight is between 45 kg and 120 kg, and your body mass index (BMI) is between 18 and 40
• You are willing to give a blood sample for genetic testing related to Parkinson's disease
• Your Parkinson's symptoms are in a mild-to-moderate range based on a standard rating scale called Hoehn & Yahr (stages 1–3)
• You do not have severe movement problems or uncontrolled involuntary movements, as judged by the study doctor
• You are either not currently taking any medication for Parkinson's, or you have been on a stable Parkinson's medication dose for at least 3 months before the study starts
• You are not pregnant or breastfeeding
• If you could become pregnant or could father a child, you agree to use two forms of contraception during the study, as specified in the study rules
• You agree not to take part in any other clinical trial while in this study
• If you have a known change (mutation) in a gene called GBA1, it must be the type that has been linked to an increased risk of Parkinson's disease

Who may not be able to join:

• You have another neurological condition such as Alzheimer's disease, multiple sclerosis, epilepsy, or certain other brain or nerve disorders
• You have a history of a condition called Gaucher disease, or your genetic results suggest a high risk of it
• You have a known genetic mutation linked to Parkinson's in a gene called LRRK2, or any other Parkinson's-related gene change other than GBA1
• You have dementia or significant memory and thinking difficulties (based on a standard cognitive test score)
• You have had an allergic reaction to the study drug (GT-02287) or any of its ingredients
• You are taking certain other medications that could interact with the study drug, including some that are broken down by the liver in a specific way — (confirm with trial site)
• You are currently taking dopamine-blocking medications (such as some antipsychotics) or certain medications that affect nerve signals (anticholinergics)
• You have certain other health conditions, including serious heart conditions, diabetes, autoimmune disease, cancer, active infections, psychotic symptoms, significant depression, or problems with alcohol or drug misuse — (confirm with trial site for full list)
• You have a condition that affects how your body absorbs food or medication through the gut
• Your routine blood or lab test results show significant abnormalities
• You have a medical reason that makes a lumbar puncture (a procedure to collect fluid from your spine) unsafe for you
• You have donated more than 500 mL of blood in the last 3 months
• You are unable to follow the study's rules about certain foods, smoking, or alcohol
• You have taken part in another clinical trial within the last 3 months (or longer, depending on the previous trial's medication)

Important: Always verify eligibility with the trial site directly before applying.