NCT06504394

Who might be able to join this trial:

• You have been diagnosed with classical Hodgkin lymphoma (a type of blood cancer) or primary mediastinal B-cell lymphoma (a type of lymphoma in the chest), confirmed by a tissue biopsy
• Your cancer can be measured on a scan, as assessed by the study doctor using standard guidelines
• You are expected to live for more than 3 months
• If you have HIV, it must be well controlled with HIV medication
• If you have hepatitis B, you must have been on hepatitis B treatment for at least 4 weeks and have no detectable virus in your blood before joining
• If you have had hepatitis C in the past, you must have completed a full course of hepatitis C treatment at least 4 weeks before joining, with no detectable virus in your blood
• You are generally well enough to carry out light daily activities (you will be assessed on a standard health scale within 7 days before starting treatment)

Who may not be able to join:

• You have serious, active heart or blood vessel disease
• You have fluid around your heart or a significant amount of fluid around your lungs
• You have another cancer that is growing or has needed active treatment in the past 2 years
• You have a condition that weakens your immune system, or have taken steroid or immune-suppressing medication within 7 days before starting the trial
• You have received a type of cancer treatment called a monoclonal antibody within the past 4 weeks, or have not recovered from side effects of earlier treatments
• You have previously been treated with certain immunotherapy drugs that target specific proteins on immune cells (called PD-1, PD-L1, or PD-L2 inhibitors) (confirm with trial site)
• You have received any cancer treatment, including experimental treatments, within 4 weeks before starting the trial
• You have had radiotherapy within 2 weeks before starting the trial, or still have side effects from radiation that need steroid treatment
• You have received a live vaccine within 30 days before starting the trial
• You are currently receiving cancer treatment not included in this trial's plan
• You have active cancer that has spread to your brain or the lining around your brain and spinal cord
• You have an autoimmune disease (where your immune system attacks your own body) that has needed treatment in the past 2 years
• You have a history of, or currently have, lung inflammation that required steroid treatment
• You have an active infection that requires treatment with medicines given throughout your body (with some exceptions — confirm with trial site)
• You currently have both hepatitis B and hepatitis C infections at the same time
• You have had a solid organ transplant at any point, or a bone marrow/stem cell transplant from a donor within the last 5 years

Important: Always verify eligibility with the trial site directly before applying.