NCT06148636

Who might be able to join this trial:

• You are between 18 and 80 years old
• You have been diagnosed with a slow-growing (grade 1 or grade 2) neuroendocrine tumor, confirmed by a tissue or cell sample
• Your cancer cannot be cured by surgery or other treatments, and it has continued to grow or worsen despite all standard treatments available to you
• You have previously received a type of radiation treatment called peptide receptor radionuclide therapy (PRRT)
• You have had a specific type of scan (called a somatostatin receptor PET/CT scan, using an FDA-approved agent) within the past 12 months that showed your tumor has certain receptors on it
• You have at least one tumor that can be measured and is at least 1 cm in size on a CT or MRI scan
• You are in good enough general health to take part (confirm with trial site)
• You do not have another active cancer that needs urgent treatment right now (some slow-growing cancers may still be acceptable with documentation from your cancer doctor)
• You do not have any serious uncontrolled illnesses, such as a major infection, serious heart problems, or conditions that would make it hard to follow the study plan
• You are able to understand the study and are willing to give your consent to take part
• You are willing and able to follow all study requirements for the full length of the study
• You agree to follow certain lifestyle guidelines during the study, including:
  • Avoiding red wine, grapefruit, Seville oranges, pomelos, and related fruit juices from the day before treatment through 5 days after each treatment
  • Taking your blood pressure medications as prescribed, if you have any
  • Avoiding excessive alcohol
  • Not taking herbal or natural supplements unless approved by your study doctor
  • Using contraception for at least 6 months if you have a uterus, or at least 3 months if you have testes

Who may not be able to join:

• Your platelet count (cells that help blood clot) is too low
• Your white blood cell count (infection-fighting cells) is too low
• Your liver function test results are too high, including bilirubin, AST, or ALT levels (confirm with trial site for exact values)
• Your kidneys are not working well enough, based on a kidney function calculation (confirm with trial site)
• You have a significant amount of protein in your urine
• You are currently pregnant or breastfeeding
• You are able to become pregnant or father a child and are not willing to use effective contraception during the study
• You are breastfeeding and unwilling to stop for the duration of the study
• You are considered to be at increased risk of falling, in the opinion of your healthcare team
• You have received any other cancer treatment, including radiation, within 2 weeks before the start of this study
• You have taken an experimental medication within 4 weeks before starting this study
• You have a history of heart failure and your heart is pumping at 40% or less of its normal capacity
• Stopping your long-acting somatostatin analogue medication (a type of hormone-blocking injection) for 24 hours would be a health risk for you, in your doctor's opinion
• You received a long-acting somatostatin analogue injection within 14 days of starting this study
• You have previously received a high dose of external beam radiation to your kidneys (above 16 Gy) (confirm with trial site)
• You have previously received significant external beam radiation or internal radiation (brachytherapy) to a large portion of your bone marrow (confirm with trial site)
• You have had a serious allergic reaction to medications that are chemically similar to the ones used in this trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.