NCT06036836

Who might be able to join this trial:

For Cohort A (skin cancer group) only:

• You have been confirmed through a tissue test to have skin squamous cell carcinoma (a type of skin cancer) that can be removed by surgery, and the cancer started in the skin (not spread from another cancer)
• Your cancer is at Stage II, III, or IV but has not spread to distant parts of the body
• You have not had any previous systemic (whole-body) treatments for this cancer
• A tumor tissue sample (either stored from before or newly taken) is available for testing
• You are 18 years of age or older at the time of signing the consent form

For Cohort B (endometrial/uterine cancer group) only:

• You have been confirmed through a tissue test to have endometrial (uterine) cancer of a specific type, where the cancer's DNA repair system is working normally (confirm with trial site)
• Your cancer is at an advanced or returning stage and cannot be treated with curative surgery or radiation
• Your cancer has gotten worse after receiving one prior chemotherapy treatment containing platinum
• Your cancer can be measured on scans before starting the trial
• You were assigned female at birth and are 18 years of age or older at the time of signing the consent form
• Your blood pressure is well controlled without needing blood pressure medication

For everyone in both groups:

• You are willing to follow the trial's guidelines on contraception if you are able to have children
• Your doctor expects you to live for more than 3 years
• Your organs (such as kidneys and liver) are working well enough
• You are generally able to carry out daily activities with no or minimal limitations (confirm with trial site)
• If you have hepatitis B, you have been on antiviral treatment for at least 4 weeks and the virus is undetectable in your blood before joining
• If you have hepatitis C, the virus is undetectable in your blood at the screening stage
• If you have HIV, it is well controlled with stable medication

Who may not be able to join:

For everyone in both groups:

• You have had a known serious allergic reaction to any of the trial's medications or similar antibody-based treatments
• You have previously received a transplant of an organ or tissue from another person

For Cohort A (skin cancer group) only:

• You have previously had radiation treatment directly to the main cancer being studied
• Your skin cancer started in the genital or anal area (such as the penis, scrotum, vulva, or area around the back passage)

For Cohort B (endometrial/uterine cancer group) only:

• You have had a major surgical procedure within 3 weeks before starting the trial
• You have a severe abnormal opening or tunnel between organs in your digestive system or elsewhere in your body (confirm with trial site)
• You have a high level of protein in your urine over a 24-hour period (confirm with trial site)
• Your heart's pumping function is below the normal range as shown on a heart scan
• Scans show that a major blood vessel is being surrounded or invaded by the tumor, or there are hollow spaces forming inside the tumor (confirm with trial site)
• You have had a significant heart condition within the 12 months before starting the trial

Important: Always verify eligibility with the trial site directly before applying.