NCT05858736

Who might be able to join this trial:

• You must be 18 years of age or older at the time of signing the consent form.
• People of all genders may apply; however, women who could become pregnant must have a negative pregnancy test before joining.
• You must be well enough to carry out light daily activities, based on a standard health performance scale (ECOG score of 0 or 1).
• You must have been diagnosed with a solid tumour (confirmed by a tissue or cell sample) that has spread or cannot be removed by surgery, and is continuing to grow.
• Your cancer must be measurable by a CT scan or chest X-ray, meaning at least one tumour or lymph node meets specific size requirements as judged by your medical team.
• Your liver, kidneys, and other organs must be working well enough, based on blood test results meeting specific levels set by the trial.
• You must be willing to take part and sign a written consent form.
• Both female and male participants must agree to use contraception as required by the trial.
• You must be expected to live for at least 12 weeks or more.

Who may not be able to join:

• You may not be eligible if you are still experiencing significant side effects from previous cancer treatments that have not sufficiently recovered (confirm with trial site for exact grade thresholds).
• You must have finished certain previous cancer treatments within a set period before joining — for example, chemotherapy or radiation at least 21 days before, and antibody-based therapies at least 28 days before.
• You cannot currently be enrolled in another clinical trial testing an experimental treatment, or be receiving other cancer treatments at the same time.
• You cannot be taking steroid medicines (such as prednisone) at doses higher than 10 mg per day within 7 days before starting the trial.
• You cannot have active cancer that has spread to the brain or the lining around the brain and spinal cord.
• You cannot have an active infection that requires antibiotic treatment given through a drip (IV) within 14 days before starting the trial (routine treatment for urinary tract infections or topical treatments are generally allowed).
• You may not be eligible if the trial doctor believes your medical history, current health, or test results could affect the trial results or put you at risk.
• You may not be eligible if you have a psychiatric condition or substance use problem that the doctor believes would make it difficult for you to follow the trial requirements.
• You cannot join if you are currently pregnant or breastfeeding.
• You cannot join if you have an active autoimmune disease that requires stronger immune-suppressing treatment than 10 mg per day of prednisone, or if you have inflammatory bowel disease or myasthenia gravis.

Important: Always verify eligibility with the trial site directly before applying.