NCT05774951

Who might be able to join this trial:

• You are a man or woman aged 18 or older at the time of screening (or meet the age requirement based on your country's guidelines)
• You have been diagnosed with a specific type of early-stage breast cancer (ER-positive, HER2-negative) that has been confirmed by a tissue sample, and your doctors have assessed it as having an intermediate or high chance of coming back
• You have already completed your main local treatment for the breast tumour, such as surgery, with or without radiation therapy, and with or without chemotherapy given before or after surgery
• You have been taking hormone-blocking therapy (and possibly an additional targeted medicine) for at least 2 years but no more than 5 years and 3 months
• You are generally well enough to carry out light activity and care for yourself (confirm with trial site)
• Your kidneys, liver, and other organs are working well enough to participate (confirm with trial site)

Who may not be able to join:

• Your breast cancer has spread to other parts of the body or cannot be removed by surgery
• Your breast cancer completely disappeared after treatment given before surgery (called a pathological complete response)
• You have had another type of cancer in the past, unless it was a minor skin cancer, early-stage cervical cell changes, or you have been cancer-free without any treatment for at least 5 years
• You have another serious or poorly controlled illness that the trial doctor believes would make participation unsafe or difficult
• You have a known weakened heart function or moderate-to-severe heart failure (confirm with trial site)
• A specific measurement of your heart's electrical activity (QTcF interval) was above a certain level at screening (confirm with trial site)
• You are currently taking any external hormone therapy (such as hormone replacement therapy)
• You are currently receiving any other cancer treatment not allowed by the trial, with the exception of certain bone-strengthening medicines
• You have previously been treated with camizestrant (the trial drug), fulvestrant, or similar experimental hormone-targeting drugs
• You are currently pregnant or breastfeeding
• You have a known allergy to camizestrant or medicines with a similar make-up, or — if you are a pre/peri-menopausal woman or a man — a known allergy or intolerance to a type of hormone-suppressing injection that may be required as part of the trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.