NCT05751629

Who might be able to join this trial:

• Your ovarian cancer got worse within 6 months of finishing at least 4 cycles of a platinum-based chemotherapy treatment (note: if your cancer progressed during or within 4 weeks of completing your very first platinum-based treatment, you would not qualify).
• You have never been treated with a type of drug called a PARP inhibitor for ovarian cancer.
• You have had 1 or 2 previous treatment courses (lines of therapy) for ovarian cancer.
• You are able to swallow and take medication by mouth.

Who may not be able to join:

• You have had a serious allergic reaction to any of the study drugs (TSR-042, bevacizumab, or niraparib) or their ingredients.
• You have a history of certain blood/bone marrow conditions called myelodysplastic syndrome or acute myeloid leukemia.
• You have an active autoimmune disease (where your immune system attacks your own body) that has needed medical treatment in the last 2 years — simple hormone replacement therapies (like thyroid or insulin) do not count as this type of treatment.
• You have previously been treated with certain immunotherapy drugs that target PD-1 or PD-L1 (a type of cancer immune treatment).
• You have previously received anti-angiogenic therapy (drugs that block blood vessel growth in tumors), unless it was bevacizumab and you stopped it for reasons other than side effects.
• You currently have a bowel blockage, had one in the last 3 months, or your doctor considers you at high risk for one; or you have a history of abdominal fistula, a hole in your gut, or an abdominal abscess; or imaging or examination shows significant bowel involvement.
• You have too much protein in your urine, as measured by certain urine tests at the start of the study (confirm specific levels with trial site).
• You are at higher risk of bleeding due to a major injury or surgery in the last 28 days, or you have had a stroke, mini-stroke, brain bleed, or significant bleeding episode in the last 3 months.
• You have been diagnosed with a blood clot in the lung (pulmonary embolism) or a deep vein blood clot in the leg within the last 3 months — though if you have a history of blood clots and have been on stable blood-thinning medication for more than 3 months, you may still be eligible (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.