NCT05633810

Who might be able to join this trial:

• You are a man or woman between 55 and 80 years old
• You have been diagnosed with type 2 diabetes and are being treated for it according to standard medical guidelines
• You have never had a heart attack, angina, or any other heart-related event caused by blocked coronary arteries
• You also have at least one of the following risk factors:
  • You have had type 2 diabetes for 5 years or more
  • Your blood sugar control (HbA1c) has been 8.0% or higher at some point in the last 2 years
  • You currently smoke cigarettes
  • You have a high level of a marker of inflammation in your blood called hs-CRP (confirm with trial site)
  • You have a high calcium buildup score in your heart arteries (confirm with trial site)
  • You have high triglyceride (fat) levels in your blood even while taking cholesterol-lowering medication
  • You have high LDL ("bad") cholesterol or high non-HDL cholesterol levels even while taking cholesterol-lowering medication
  • You have high levels of a protein called Apolipoprotein B in your blood (confirm with trial site)
  • You have low HDL ("good") cholesterol levels
  • You have high levels of a protein called Lp(a) in your blood (confirm with trial site)
  • You have significant narrowing or previous surgery to open up arteries in your legs or other limbs
  • You have significant narrowing or previous surgery to open up arteries leading to your brain
  • You have diabetes-related eye damage or nerve damage
  • You have a mild or moderate level of protein detected in your urine
• If you are a woman who could become pregnant, you must have a negative pregnancy test at the start of the study and agree to use a reliable form of birth control throughout the study (such as the pill, an implant, an IUD, condoms with spermicide, abstinence, or having a sterilised partner)
• If you are a woman who cannot become pregnant — because you have had your uterus or fallopian tubes removed, or you have gone through menopause (no periods for 12 months) — this condition does not apply to you
• You are able to understand the study and give your own consent to take part

Who may not be able to join:

• You have ever had a heart attack, chest pain (angina), a procedure to open blocked heart arteries, a stroke, a mini-stroke (TIA), significant narrowing of the heart arteries, or heart failure
• Your kidneys are not working well enough, based on a specific blood test measurement (confirm with trial site)
• You have been diagnosed with cancer or a blood/lymph system disease in the last 3 years — with some exceptions for certain successfully treated skin cancers, a localised cervical condition, or low-grade prostate cancer
• You have inflammatory bowel disease (Crohn's disease or ulcerative colitis) or ongoing long-term diarrhoea
• You have had a stomach ulcer in the last 2 years, or have previously had serious bleeding in your digestive system (minor haemorrhoidal bleeding more than 5 years ago may be allowed — confirm with trial site)
• You have a pre-existing progressive muscle or nerve disease, or your muscle enzyme levels (CPK) in your blood are significantly elevated
• You have certain abnormal blood test results, including low red blood cells (anaemia), low white blood cells, low platelets, or elevated liver markers (confirm specific values with trial site)
• You have cirrhosis, ongoing active hepatitis, or severe liver disease
• You are pregnant, breastfeeding, or planning to become pregnant during the study or within 6 months of finishing the study medication
• You have had a significant problem with drug or alcohol misuse in the past year
• You are currently taking, or plan to take, long-term steroid tablets or injections during the study (steroid creams, inhalers, or replacement therapy for adrenal conditions are generally allowed)
• You are currently taking aspirin or another blood-thinning antiplatelet medicine on a regular basis (you may still be eligible for part of the study — confirm with trial site)
• You are currently taking a regular anticoagulant (blood-thinning) medicine (you may