NCT05508867

Who might be able to join this trial:

• You have been diagnosed with classical Hodgkin lymphoma (a specific type of blood cancer), confirmed by a tissue biopsy, that shows up on a specific type of PET scan (FDG-PET).
• Your lymphoma has either come back after treatment or never fully responded to treatment, and you have run out of standard treatment options that are known to help.
• Your cancer continued to grow or spread while you were being treated with a type of immunotherapy drug called an anti-PD-(L)1 antibody (such as pembrolizumab or nivolumab), either alone or combined with other treatments.
• You are able to provide a tumor tissue sample — either one taken within the last 5 years or a newly collected one — that has not been treated with radiation.

Who may not be able to join:

• You have a condition that weakens your immune system, or you are currently taking steroids or other medicines that suppress your immune system on an ongoing basis.
• Your cancer has spread to your brain or spinal cord, or you have had this in the past.
• You have an autoimmune disease (where the body attacks itself) that needed medical treatment within the last 2 years, not including simple hormone replacement therapy.
• You have had lung inflammation (pneumonitis) or scarring of the lungs (interstitial lung disease) in the past that required steroid treatment, or you currently have this condition.
• You currently have an infection that requires treatment with medicines.
• You have a history of a rare and serious immune condition called hemophagocytic lymphohistiocytosis (confirm with trial site).
• You have a seizure disorder that is not well controlled with medication.
• You have a significant or active heart or blood vessel condition.
• You have received any cancer treatment, including experimental treatments, within the 4 weeks before joining the trial.
• You have received radiation therapy within 2 weeks before starting the trial, or you are still experiencing side effects from radiation that require steroid treatment.
• You have recently had a major surgery and have not yet fully recovered.
• You have another cancer that is still being treated or has required active treatment within the past 3 years.
• You have a history of HIV infection.
• You have received a donor stem cell transplant or an organ transplant within the last 5 years.

Important: Always verify eligibility with the trial site directly before applying.