NCT05317078

Who might be able to join this trial:

• You are 18 years of age or older.
• You have a solid tumor cancer that has been confirmed by a lab test, and your tumor produces a protein called claudin-6 (CLDN6) — this may include lung cancer, ovarian cancer, testicular cancer, uterine cancer, or triple-negative breast cancer, among others.
• Your cancer has spread to other parts of the body or cannot be removed by surgery.
• You have already tried standard available cancer treatments, or you are not a suitable candidate for those treatments.
• You are generally able to carry out basic daily activities with little or no limitation (your doctor can assess this).
• Your heart, liver, kidneys, and other organs are working well enough to participate.
• You are expected to live for more than 3 months.
• For certain parts of the trial, a tissue sample from your tumor must be available and must show that the claudin-6 protein is present.
• For certain expanded parts of the trial, you must have at least one measurable tumor spot of 10mm or larger that has not been biopsied in the last 3 months.
• You have given your written agreement to take part before any study procedures begin.

Who may not be able to join:

• You have tested positive for HIV, hepatitis B, or hepatitis C.
• You have been diagnosed with another type of cancer within the past 2 years.
• You currently have signs of an active, uncontrolled infection in the week before starting the study treatment.
• You have cancer that has spread to the brain or spinal cord that is new, growing, or causing symptoms — though people with stable, previously treated brain metastases may still be eligible (confirm with trial site).
• You are currently taking part in another clinical trial, or finished one less than 4 weeks ago.
• You have received chemotherapy, radiation, or certain targeted cancer treatments within the past 2 weeks (or longer, depending on the specific drug), or immunotherapy within the past 3 weeks.
• You have had major surgery within the past 4 weeks (minor procedures like biopsies do not count).
• You have an autoimmune condition (such as Crohn's disease or ulcerative colitis) that requires ongoing steroid or immune-suppressing medication.
• You are a woman who could become pregnant and are unwilling to use the contraception methods required by the study, or you are currently breastfeeding or planning to become pregnant.
• You are a man with a female partner who could become pregnant, and you are unwilling to use the required contraception methods or abstain from donating sperm.
• You have a known allergy or sensitivity to any of the study medications or their ingredients.
• You are unlikely to be able to attend all required study visits or follow the study procedures.
• You have another significant health condition that, in the doctor's opinion, could put you at risk or interfere with the study (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.