NCT04569773

Who might be able to join this trial:

• You are a woman between 18 and 50 years old
• You have not yet gone through menopause
• Your uterine cancer has been identified as a specific type called "endometrioid" based on tissue testing
• You are scheduled to have surgery at Memorial Sloan Kettering Cancer Center (MSKCC)
• Your cancer is an early stage (FIGO grade 1–2, stage I), meaning it appears to be at a lower severity and has not spread
• Scans (preferably MRI) show the cancer is contained within the uterus and has not grown deeply into the uterine wall
• Your ovaries appear normal on pre-surgery scans
• You are able to give your informed consent to participate
• You are an English speaker

Who may not be able to join:

• You have been diagnosed with Lynch syndrome (an inherited condition that increases cancer risk)
• You have previously had both ovaries surgically removed
• You have a personal history of hormone receptor-positive breast cancer
• You or close family members have a history that suggests an increased risk of ovarian cancer
• You are currently taking hormonal contraception, letrozole, or tamoxifen — this may prevent you from taking part in one specific part of the study (confirm with trial site)
• You have had ovarian stimulation (such as for fertility treatment) within the last 3 months — this may affect eligibility for one part of the study (confirm with trial site)
• You have a condition affecting your pituitary gland — this may affect eligibility for one part of the study (confirm with trial site)
• You finished chemotherapy less than 12 months ago — this may affect eligibility for one part of the study (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.