NCT04353492

Who might be able to join this trial:

• You have been diagnosed with multiple sclerosis (MS) according to a specific set of recognised diagnostic guidelines (the 2017 McDonald criteria)
• You have a relapsing form of MS, which includes relapsing MS or a type called secondary progressive MS that still has active flare-ups
• Your level of physical disability, measured by a standard MS scoring system, falls within a mild to moderate range (confirm with trial site)
• You have previously been treated with no more than 3 different MS medications in total (with a specific group of similar medicines counting as just one)
• Your most recent MS medication — taken for at least 6 months — was either a fumarate-based therapy (such as dimethyl fumarate or diroximel fumarate) or a medicine called fingolimod, and you are now switching away from it
• While taking your fumarate or fingolimod medication, your MS showed signs of still being active — such as having one or more relapses, or new activity showing up on an MRI scan
• Your MS has been neurologically stable for at least one month before starting the trial

Who may not be able to join:

• You have primary progressive MS, or a form of secondary progressive MS with no active disease
• You have a condition called neuromyelitis optica
• It has been more than 10 years since you were first diagnosed with MS
• You are currently pregnant or breastfeeding
• You are a woman who could become pregnant and are not using a highly effective form of contraception during the study and for at least 6 months after finishing the study medication
• You have another active long-term condition affecting your immune system, or a condition that weakens your immune system
• You currently have an active bacterial, fungal, or viral infection (such as hepatitis, HIV, or COVID-19), or have been diagnosed with AIDS
• You have symptoms that suggest, or a confirmed diagnosis of, a serious brain infection called Progressive Multifocal Leukoencephalopathy (PML)
• You are considered at risk of syphilis or tuberculosis, or have a history of either condition, even if previously treated
• You have active hepatitis B or hepatitis C
• You have received a live vaccine within 4 weeks before starting the trial
• You have previously taken certain specific MS or immune-related medications within particular timeframes (confirm with trial site for the full list)
• In the opinion of the trial doctor, you may not be able or willing to follow the study requirements

Important: Always verify eligibility with the trial site directly before applying.