NCT04173273

Who might be able to join this trial:

• You are a man or woman between 18 and 80 years old
• You are able to give written consent and are able to follow the schedule of visits and assessments required by the trial
• You have been diagnosed with Crohn's disease for at least 3 months
• Your Crohn's disease is considered moderately to severely active at the time of screening
• You have tried at least one of the following treatments and either did not respond to it, stopped responding over time, or could not tolerate it: steroid tablets (such as prednisone or budesonide), immune-suppressing medicines (such as azathioprine, 6-mercaptopurine, or methotrexate), or certain biologic injection/infusion treatments (such as infliximab, adalimumab, certolizumab, vedolizumab, or ustekinumab)
• If you are a woman who could become pregnant, you must not currently be pregnant
• If you are a woman who could become pregnant, or a man, you must agree to use contraception during the trial
• For Substudy 3: You must have previously participated in and completed a specific visit during the extended induction period of Substudy 1 or Substudy 2 (confirm with trial site)
• For Substudy 4: You must have completed a specific week 52 or week 66 visit in an earlier part of the trial (confirm with trial site)

Who may not be able to join:

• You have not responded to two or more different classes of biologic treatments (such as TNF-blockers, interleukin blockers, or integrin blockers) for Crohn's disease
• You have another type of bowel condition, such as ulcerative colitis, microscopic colitis, ischemic colitis, toxic megacolon, or an active bowel infection, or you test positive for a bacteria called Clostridioides difficile at screening
• You have short bowel syndrome or related complications that may need surgery or affect how the trial measures results
• You had surgery to treat an abscess inside your abdomen within the last 8 weeks, or surgery for an abscess near your back passage within the last 4 weeks
• You had a portion of your intestine removed within the last 24 weeks, or any other abdominal surgery within the last 12 weeks
• You have a stoma bag (ileostomy or colostomy)

Important: Always verify eligibility with the trial site directly before applying.