NCT03884647

Who might be able to join this trial:

• You are between 50 and 75 years old (inclusive) and are either male or female.
• You have at least one risk factor for stroke or dementia — this includes things like a previous stroke or mini-stroke (TIA), high blood pressure, high cholesterol, diabetes, an irregular heartbeat (atrial fibrillation), other heart conditions (such as a past heart attack or valve problems), current or past heavy smoking (more than 20 cigarettes a day), being overweight or obese (BMI over 25), a family history of dementia, being aged 65 or older, or having sleep problems.
• You or a family member have noticed memory or thinking problems, or there is some objective evidence of cognitive (thinking/memory) difficulties.
• You are willing to take part in all parts of the study.

Who may not be able to join:

• You have a degenerative brain or nervous system disease (confirm with trial site).
• You have a neurological condition present from birth or early development, such as cerebral palsy, brain damage from lack of oxygen, or autism spectrum disorder.
• You have Multiple Sclerosis (MS).
• You have a major mental health condition such as PTSD, bipolar disorder, schizophrenia, or a substance use disorder.
• You have a chronic (long-term) pain condition.
• You have a history of a brain tumor, brain surgery, or radiation treatment to the brain.
• You have ever had an epileptic seizure.
• You have any metal implants in your brain, such as a shunt, pacemaker, clips, coils, bullet fragments, or cochlear implants.
• You have any implanted device controlled by body signals, or any magnetic metal implanted in your head or within 30 cm of the treatment area.
• You have any reason you cannot have an MRI scan.
• You have had a significant head injury in the past, such as losing consciousness or being diagnosed with a brain bruise (contusion) after a head injury.
• You are currently taking opioid painkillers, antipsychotic medications, or anti-epileptic medications.
• You have taken sleeping pills, antidepressants (SSRIs), or anti-anxiety medications within 12 hours before the study evaluation.
• You currently use recreational drugs.
• You are pregnant or breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.