NCT03814603

Who might be able to join this trial:

• You are a man or woman between 60 and 75 years old with normal memory and thinking abilities.
• Your neurological (brain and nervous system) and mental health check-ups are within normal ranges, with no signs of cognitive decline.
• A family member or close companion (preferably someone you live or sleep with) is available to answer a few questions by phone or in person to confirm information you provide.
• You identify yourself as African-American Black or non-Hispanic white.
• You are willing and able to sign the Alzheimer's Disease Center consent form.

Who may not be able to join:

• You have a history of brain tumors, significant brain injury, seizures, hydrocephalus (fluid on the brain), intellectual disability, Parkinson's disease, or other serious brain or nervous system conditions.
• You have a significant history of alcohol misuse (based on a short questionnaire) or drug abuse.
• You have a history of serious mental health conditions such as schizophrenia, bipolar disorder, or PTSD.
• You have had an active episode of depression or anxiety within the last two years (a long-term history of depression or anxiety that is currently stable may be acceptable — confirm with trial site).
• You score above 6 on a short depression screening questionnaire called the Geriatric Depression Scale.
• You require insulin to manage diabetes.
• You have significant heart, lung, hormonal, or blood-related health conditions, based on the doctor leading the trial's judgment.
• You have a physical limitation severe enough to affect the reliability of memory and thinking tests.
• You have any implanted medical devices (such as a pacemaker or surgical clips) that are not safe for MRI scans.
• You currently take certain medications that can affect memory, thinking, or deep sleep — including narcotic painkillers, some Parkinson's medications, antidepressants of specific types, or a range of other listed medications (confirm with trial site for the full list).
• You have a close blood relative (parent or sibling) who developed dementia before age 60.
• You regularly sleep fewer than 5 hours or more than 10 hours per day.
• You have been diagnosed with obstructive sleep apnea meeting specific severity criteria (confirm with trial site).
• You identify as Caribbean Black (US-born or Caribbean-born) or African-born Black.

Important: Always verify eligibility with the trial site directly before applying.