NCT03746431

Who might be able to join this trial:

• You have been confirmed by a lab test to have an advanced solid tumour cancer that has not responded to standard treatments, has no standard treatments available, or you have chosen not to have standard treatment.
• Your cancer can be measured or tracked using standard imaging scans.
• You are generally well enough to carry out light activity and care for yourself (your doctor will assess this using a standard scale).
• Your doctor believes you are likely to live for more than 3 months.
• There is tumour tissue available from either a previous biopsy or a new one, which can be tested in a lab (this does not need to be sent in before you join).
• Your heart, kidneys, and liver are working well enough to participate.
• Your blood counts are at an acceptable level, showing your bone marrow is functioning adequately.
• You are able to understand and are willing to sign a consent form agreeing to take part.
• (For Phase 2 of the trial only) Your cancer is one of the following specific types: endometrial, cervical, ovarian, triple-negative breast cancer, HER2-negative breast cancer, head and neck squamous cell carcinoma, adenoid cystic carcinoma, or uveal melanoma — and it is advanced, has spread, cannot be removed by surgery, or has come back.
• (For Phase 2 only) Your cancer has not responded to standard treatment, or no standard treatment exists or is suitable for you.
• Before receiving the treatment, a special imaging scan must show that at least one area of your cancer has enough of a specific protein target for the treatment to work.

Who may not be able to join:

• You have received a radioactive drug used as a cancer treatment within the last 6 months.
• You are unable to have the required imaging scans for any reason — for example, if you cannot lie flat for the length of the scan.
• You have cancer that has spread to the brain and is not currently under control, or requires treatment with steroids, surgery, or radiation.
• You have had any cancer treatment (including experimental treatments) or external radiation therapy within the 14 days before your first imaging scan for this trial.
• You have another cancer that is growing or has needed active treatment within the past 3 years (though certain skin cancers or early-stage cancers that have been successfully treated may still be eligible — confirm with trial site).
• You still have significant side effects (rated moderate or above) from a previous cancer treatment, except for moderate hair loss.
• You have previously had an organ transplant, including a bone marrow or stem cell transplant.
• You have previously been treated with certain specific chemotherapy drugs called nitrosoureas or actinomycin-D.
• You have a clinically significant amount of protein in your urine (confirm with trial site).
• You have a known or suspected allergy or sensitivity to the drugs used in this trial or any of their ingredients.
• You have other serious uncontrolled health conditions, such as an active infection, uncontrolled heart failure, unstable chest pain, an irregular heartbeat, uncontrolled diabetes, or a mental health or personal situation that would make it hard to follow the trial requirements.
• You have previously received more than 20 Gray (a unit of radiation dose) of radiation to large parts of your bone marrow.

Important: Always verify eligibility with the trial site directly before applying.