NCT03733314

Who might be able to join this trial:

• You have been diagnosed with Crohn's disease (affecting the small intestine, large intestine, or both) for at least 12 weeks before agreeing to take part.
• Your Crohn's disease is currently moderate to severe, based on two specific scoring systems used by doctors (confirm with trial site for exact score details).
• A camera examination of your bowel (colonoscopy) during the screening period showed a certain level of disease activity, including the presence of at least one ulcer, as confirmed by a central review team.
• You have previously tried steroid or immune-suppressing medicines but they did not work well enough, you could not tolerate them, or you became dependent on steroids; or you have tried a biologic medicine that either never worked, stopped working over time, or caused side effects you could not tolerate.
• If you are currently taking certain anti-inflammatory medicines or antibiotics for Crohn's disease, your dose has not changed in at least the last 4 weeks.
• If you are currently taking a low dose of oral steroid medication (such as prednisolone or budesonide), your dose has not changed in at least the last 4 weeks.
• If you are currently taking certain immune-suppressing medicines (such as azathioprine, 6-mercaptopurine, or methotrexate), your dose has not changed in at least the last 8 weeks.

Who may not be able to join:

• You have been diagnosed with ulcerative colitis or a type of bowel disease that is unclear between Crohn's and ulcerative colitis (called indeterminate colitis).
• You have been diagnosed with abnormal or pre-cancerous changes in the lining of your digestive tract.
• You currently have, or are suspected to have, a pocket of infection (abscess) in your abdomen.
• You have a stoma bag (artificial opening for waste), an ileo-anal pouch, or a fistula (an abnormal channel between body parts).
• You have a significant or symptomatic narrowing in your bowel that requires a procedure to widen it, or has been rated as severely narrow during your colonoscopy assessment.
• You have had part of your small bowel surgically removed and as a result have difficulty absorbing enough nutrition (known as short bowel syndrome).

Important: Always verify eligibility with the trial site directly before applying.