NCT03414047

Who might be able to join this trial:

• You are a woman diagnosed with a specific type of ovarian, peritoneal, or fallopian tube cancer called "high-grade serous."
• (Cohorts 1–3) Your cancer has stopped responding to platinum-based chemotherapy, and you have had genetic testing done on your BRCA1 and BRCA2 genes before starting the study treatment.
• (Cohort 1) Your BRCA test came back negative, and you have already received 3 or more different rounds of cancer treatment.
• (Cohort 2) Your BRCA test came back negative, and you have received fewer than 3 prior rounds of cancer treatment.
• (Cohort 3) Your BRCA test came back positive, and you have previously been treated with a type of drug called a PARP inhibitor.
• (Cohort 4) Your cancer did not respond to platinum-based chemotherapy from the very beginning.
• Your liver, kidneys, and other organs are working well enough to safely participate.
• You are willing and able to have a small sample of your tumor removed (biopsy) as required by the study.

Who may not be able to join:

• (Cohorts 1–3) You have already received all three of the following chemotherapy drugs during your platinum-resistant treatment: gemcitabine, pegylated liposomal doxorubicin, and paclitaxel.
• Your cancer has spread to your brain or spinal cord.
• You have previously taken part in a study involving a specific type of drug called a "checkpoint kinase 1 inhibitor," or you are known to be allergic to the study drug or its ingredients.
• You have a history of an abnormal opening or tear in your abdomen or digestive tract (fistula or perforation), an infection inside your abdomen in the last 3 months, or a confirmed bowel blockage in the last 3 months.
• You have an active HIV infection that is causing symptoms, or an active hepatitis A, B, or C infection that is causing symptoms.
• You have a serious heart condition.
• You have previously had radiation therapy covering your entire pelvic area.
• You take corticosteroid (steroid) tablets or injections every day on an ongoing basis — steroid inhalers or creams applied to the skin are allowed.
• You have known factors that could raise your risk of infection during the study, such as a drainage tube placed in your abdomen or open wounds (confirm with trial site for full details).

Important: Always verify eligibility with the trial site directly before applying.