NCT03378297

Who might be able to join this trial:

• You have been diagnosed with advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer (at least stage 3).
• You are 18 years of age or older.
• You have not previously received any treatment for gynaecological cancer (women previously treated for cervical cancer or pre-cancerous changes on the cervix may still qualify if that treatment finished at least one year before your current diagnosis).
• Your blood test results meet certain minimum health levels, including acceptable counts for white blood cells, platelets, haemoglobin, kidney function, liver function, blood sugar (HbA1c), and blood clotting — all tested within 14 days before starting the study drug.
• You are able to read and understand a consent form and are willing to sign it.
• You have suitable veins for the blood samples required by the study.

Who may not be able to join:

• You are unable to understand the study information or give your consent due to language barriers, mental capacity, or your illness.
• You are unable to swallow or take medication by mouth.
• You are currently pregnant.
• You have had a previous allergic reaction to a drug with a similar composition to the study drug (confirm with trial site).
• You have a history of blood clotting problems or a known bleeding disorder.
• You are known to be hepatitis B surface antigen positive, have HIV, or have or are suspected to have an active hepatitis C infection.
• You have been diagnosed with or treated for another cancer within the last year, or you have a previous cancer that has not been fully cleared — except for certain skin cancers or fully removed non-invasive cancers.
• You are currently taking part in, or have taken part in, another clinical study involving medication within the last four weeks.
• You have an immune deficiency disorder, or have received immune-suppressing medication within the last 7 days (low-dose corticosteroids may be acceptable — confirm with trial site).
• Your cancer type has been confirmed by biopsy to be something other than high-grade serous ovarian cancer.
• You have active cancer spread to the brain or the lining around the brain.
• You currently have an active infection that requires treatment.
• You currently have a bowel blockage (obstruction).
• You have certain serious health conditions, including severe kidney failure (stage 4 or above), significant heart failure (NYHA grade III or above), a history of severe psychiatric illness, or a current diagnosis of alcoholism or drug addiction.

Important: Always verify eligibility with the trial site directly before applying.