NCT03358472

Who might be able to join this trial:

• Your cancer must be measurable using standard imaging scans (based on specific medical guidelines called RECIST v1.1).
• You must be fairly active and able to carry out normal daily activities with little or no limitation (a doctor will assess this using a standard scale).
• Your heart, liver, kidneys, and other organs must be working well enough to meet the trial's health requirements.
• If you have cancer of the oropharynx (the back of the throat/mouth area), you must have been tested for a virus called HPV and have those results available.
• You must either have a stored tumor tissue sample available, or be willing to have a small piece of tumor tissue removed before treatment starts (from a tumor that has not been previously treated with radiation).

Who may not be able to join:

• Your cancer cannot be a type that started in the nasopharynx, salivary glands, or is of unknown origin, or is not a squamous cell type of head and neck cancer.
• You cannot join if your cancer got worse within 6 months of finishing a previous treatment that was intended to cure your head and neck cancer.
• You cannot have received certain prior or ongoing treatments that are not allowed under the trial's rules (confirm with trial site).
• You cannot have another cancer that is currently growing or has needed active treatment in the past 3 years.
• You cannot have active cancer that has spread to the brain or the lining around the brain or spinal cord.
• You cannot have an active autoimmune disease (where your immune system attacks your own body) that needed medical treatment in the past 2 years.
• You cannot have a known history of HIV infection.
• You cannot have an active hepatitis B or hepatitis C infection, confirmed by specific blood tests.

Important: Always verify eligibility with the trial site directly before applying.