NCT03352557

Who might be able to join this trial:

• You have experienced a slow, gradually worsening change in memory that has been happening for more than 6 months.
• You have been diagnosed with mild cognitive impairment (MCI) or mild Alzheimer's disease, based on standard medical assessments.
• Your memory and thinking problems have been confirmed through specific tests at a screening visit (confirm with trial site for exact test details).
• Your score on a standard memory and thinking test (called the MMSE) falls between 22 and 30 out of 30.
• Your scores on a standard disease rating scale (called the CDR) meet specific levels showing mild impairment (confirm with trial site for exact score requirements).
• You are willing to have a genetic test related to Alzheimer's risk (called ApoE genotyping).
• You have a family member, friend, or carer who knows you well and can take part in the study alongside you as a "study partner."
• A brain scan or other test has confirmed the presence of a protein linked to Alzheimer's disease (called amyloid beta) in your body.

Who may not be able to join:

• You have another medical or brain-related condition (other than Alzheimer's) that could be causing your memory problems or that could affect your safety or ability to take part.
• You have a significant and unstable mental health condition, such as severe psychiatric illness.
• You have had a stroke, a mini-stroke (TIA), or an unexplained loss of consciousness in the past year.
• You have a history of significant bleeding in the brain, a blood clotting disorder, or abnormal blood vessels in the brain.
• You have had unstable chest pain (angina), a heart attack, serious heart failure, or significant heart rhythm problems within the past year.
• You have signs of poor kidney or liver function.
• You have had a problem with alcohol or drug misuse in the past year.
• You have had a significant illness or serious infection within the 30 days before or during the screening period.
• You are taking medications for ongoing conditions whose doses have not been stable for at least 4 weeks before screening, or Alzheimer's medications that have not been at a stable dose for at least 8 weeks before screening.
• You are taking any medication that, in the doctor's opinion, could affect your memory and thinking, increase your risk of side effects, or interfere with study tests and procedures.
• You have any other reason that would make the study procedures unsafe or unsuitable for you (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.