NCT03088670

Who might be able to join this trial:

• You are between 18 and 78 years old
• You have been officially diagnosed with type 2 diabetes
• You have either never taken diabetes medication, or you have not taken any diabetes-lowering medication for at least 12 weeks before the screening visit
• You are willing to use an appropriate method of contraception throughout the study
• Your body mass index (a measure of weight relative to height) is between 22 and 40
• Your HbA1c (a blood test showing average blood sugar over roughly 3 months) is between 7.5% and 11.0%
• Your fasting blood sugar level is below 15 mmol/L (a blood test taken after not eating)
• You are willing and able to sign a consent form agreeing to take part
• You are able and willing to follow all the study requirements throughout the trial

Who may not be able to join:

• You are pregnant, breastfeeding, planning to become pregnant during the study, or are a woman who could become pregnant and is not using an adequate method of contraception (confirm with trial site)
• You have a history of type 1 diabetes or any other type of diabetes besides type 2
• You have had a serious diabetes-related emergency, such as diabetic ketoacidosis or a hyperosmolar coma, within 6 weeks before screening (confirm with trial site)
• You have serious diabetes complications, such as advanced eye disease, nerve damage affecting your internal organs, or a condition where your stomach empties too slowly
• You have a known allergy or sensitivity to the study medications (Gosogliptin, Vildagliptin, or Metformin) or any of their ingredients
• You have a seizure disorder, a systemic autoimmune or connective tissue disease requiring treatment with steroids or chemotherapy drugs, or have been diagnosed with cancer in the last 5 years (except a certain type of minor skin cancer)
• You have had a significant heart or blood vessel problem in the last 12 months, including serious heart failure, uncontrolled irregular heartbeat, unstable chest pain, heart attack, heart surgery, stroke or mini-stroke, severely uncontrolled high blood pressure, or a blood clot in the lungs or legs
• You have serious kidney problems, including kidney disease, high creatinine levels in your blood, or reduced kidney function below a certain level
• You have hepatitis B, hepatitis C, liver cirrhosis, significantly raised liver enzyme levels, or high bilirubin levels (a measure of liver function)
• You have HIV, or have had a serious infection that affected your blood sugar levels within 30 days before screening
• You have anaemia (low red blood cell levels), have donated more than 500 mL of blood, or received a blood transfusion within 12 weeks before screening
• You currently misuse drugs or alcohol
• You have taken part in another clinical trial and received a study drug within 30 days before screening
• You are unable to read or write, or are unwilling to understand and follow the study procedures

Important: Always verify eligibility with the trial site directly before applying.