NCT02870634

Who might be able to join this trial:

• You have signed a consent form before any study procedures begin
• You have been diagnosed with ALS (also called Motor Neurone Disease), whether inherited or not, at any stage from "possible" to "definite" based on standard diagnostic guidelines
• Your first ALS/MND symptoms appeared no more than 2 years before your screening appointment
• Your lung function tests show your breathing capacity and nasal sniff pressure are at or above certain minimum levels (at least 70% and 50% of what is expected for someone your age and size)
• You are either not taking riluzole, or you have been on a stable dose of riluzole for at least 4 weeks before screening (you cannot start riluzole during the study)
• You are between 18 and 75 years old when you sign the consent form
• You have a reliable caregiver who is able and willing to help you take the study medication
• Your blood test results show your bone marrow, kidneys, and liver are functioning well enough (confirm specific numbers with trial site)
• If you could become pregnant, you must use effective contraception during the study, not be breastfeeding, and have a negative pregnancy test at screening; this applies to male participants whose partners could become pregnant as well

Who may not be able to join:

• You have difficulty swallowing tablets or have a gut condition that may stop the study drug from being properly absorbed
• You rely on a breathing machine (invasive or non-invasive) for any part of the day or night
• You have taken part in another clinical trial within the last 3 months, or two other trials within the last 6 months
• You have had an active stomach or bowel condition (other than acid reflux) within 30 days of your screening visit
• You have a condition or are receiving treatment that weakens your immune system
• You have any of the following: drug or alcohol dependency, an unstable heart, lung, kidney, liver, hormone, or blood disorder, an active infection, HIV/AIDS, current cancer, an unstable psychiatric condition such as psychosis or untreated severe depression within 90 days of screening, or any other muscle or nerve disease besides ALS/MND
• You have dementia that could affect the study results or your ability to understand and follow the study requirements
• You have been using blood-thinning medication at treatment doses within 7 days before your screening visit
• You are currently taking certain medications that strongly affect how the body processes drugs (confirm specific medications with trial site)

Important: Always verify eligibility with the trial site directly before applying.