NCT02566993

Who might be able to join this trial:

• You must be willing and able to give written consent to take part voluntarily
• You must be 18 years old or older
• You must have been diagnosed with small-cell lung cancer (SCLC) — confirmed by a lab test on a tissue or cell sample — and have already tried one chemotherapy treatment that included a platinum-based drug, with your cancer getting worse at least 30 days after that treatment ended
• You may also be eligible if you have a small-cell cancer from an unknown starting point in the body, confirmed by specific lab tests showing a certain level of tumor cell activity (confirm with trial site)
• You must be well enough to carry out basic daily activities — rated on a standard scale used by doctors (confirm with trial site)
• Your blood, kidney, liver, and other body functions must be working well enough, checked within about 1–2 weeks before joining the trial
• It must be at least 3 weeks since your last cancer treatment, and your body must have recovered from any side effects of that treatment
• If you had radiation to the whole brain, it must be at least 4 weeks ago; if you had preventive brain radiation or radiation to another area, it must be at least 2 weeks ago
• Women who could become pregnant must agree to use highly effective contraception during the trial and for 6 weeks after treatment ends; men whose partners could become pregnant must use condoms during treatment and for 4 months after the last dose

Who may not be able to join:

• You have had more than one course of chemotherapy treatment for this cancer
• You have never received a platinum-based chemotherapy for your small-cell lung cancer
• You have previously been treated with specific drugs called PM01183, topotecan, or anthracyclines
• Your cancer is at an early/limited stage and could still be treated with local or targeted treatment to a specific area
• You may need radiation therapy or surgery within 4 weeks before joining the trial due to bone fractures or pressure on the spinal cord
• You have cancer that has spread to the brain or nervous system and is causing symptoms, getting worse, or requires steroid medication, within 4 weeks before joining the trial
• You have certain serious heart conditions, such as chest pain, a recent heart attack, heart failure, or irregular heartbeat
• You have a weakened immune system, including a known HIV diagnosis
• You have an ongoing or actively treated long-term liver condition
• You have an active infection or have needed extra oxygen within 2 weeks before joining the trial
• You have a lung condition such as widespread scarring or thickening of lung tissue
• You have a second cancer that has been treated with chemotherapy or radiation
• You have had a serious fungal infection requiring treatment within 12 weeks before joining the trial
• You are pregnant or currently breastfeeding

Important: Always verify eligibility with the trial site directly before applying.