NCT02240680

Who might be able to join this trial:

• You must be willing to sign a consent form agreeing to take part in the trial before any assessments begin.
• You must have been diagnosed with Type 2 Diabetes.
• You must be 60 years of age or older when you sign the consent form.
• You must have been taking a stable dose of a long-acting (basal) insulin for at least 4 weeks before joining, with only small dose changes (up to 20% either way) allowed.
• You may or may not be taking metformin, but if you are, your dose must have been stable for at least 12 weeks before joining.
• You may or may not be taking certain diabetes tablets called alpha-glucosidase inhibitors (such as acarbose), but if you are, your dose must have been stable for at least 12 weeks before joining.
• Your HbA1c (a blood test that shows average blood sugar levels over time) must be between 7.0% and 10.0% at your first visit.
• Your BMI (a measure of body weight relative to height) must be 45 or below at your first visit.
• In the opinion of the trial doctor, you must be willing and able to follow all trial requirements reliably.

Who may not be able to join:

• People who have significant difficulties with memory or thinking, based on a mental status test given at the first visit.
• People showing signs of depression, based on a questionnaire score of 10 or more at the first visit.
• People who have Type 1 Diabetes (rather than Type 2).
• People who have had a heart attack, unstable chest pain, stroke, or mini-stroke (TIA) within the 3 months before their first visit.
• People whose liver blood tests show results more than 3 times higher than normal at the screening or run-in stage.
• People who have had weight-loss surgery (such as gastric bypass or gastric banding) within the past 2 years.
• People who have had cancer or received cancer treatment within the last 5 years (skin cancers that were fully removed and were not invasive may be an exception — confirm with trial site).
• People who have certain blood disorders that affect red blood cells, such as haemolytic anaemia, malaria, or babesiosis.

Important: Always verify eligibility with the trial site directly before applying.