NCT02179970

Who might be able to join this trial:

• You are 16 years old or older at the time of signing the consent form.
• (For the dose escalation part of the trial) You have been diagnosed with inoperable, advanced or spread pancreatic cancer, high-grade serous ovarian cancer, or colorectal cancer that has not responded to standard chemotherapy, or you have chosen not to have standard chemotherapy.
• (For the expansion part of the trial) You have been diagnosed with inoperable, advanced or spread pancreatic cancer that has not responded to standard chemotherapy, or you have chosen not to have standard chemotherapy.
• Your tumour can be safely accessed for a small tissue sample (biopsy) and testing.
• You are generally able to carry out daily activities with little or no restriction (confirm with trial site what this means for your situation).
• Your doctors expect you to live for at least 12 weeks.
• If you are a woman who could become pregnant, or a sexually active man, you must agree to use effective contraception throughout the study and for 3 months after the last dose of the study drug.

Who may not be able to join:

• Your blood cell counts or clotting levels are too low, as shown by specific blood test results (confirm with trial site for exact values).
• Your kidneys are not working well enough, based on a specific blood test measurement.
• Your liver is not working well enough, based on specific blood test results.
• You have received chemotherapy, steroids, or other drugs that suppress the immune system within the last 28 days.
• You have a significant ongoing or serious physical or mental health condition that the trial doctor believes could put you at risk or affect the study results.
• You have a history of serious heart rhythm problems, use a pacemaker, have had a heart attack in the past 6 months, or have a known history of a significant drop in blood pressure when standing up.
• You currently have an active infection.
• You have a known allergy to the study drug (plerixafor) or any of its ingredients.
• You are known to have hepatitis B, hepatitis C, or HIV.
• You are pregnant, planning to become pregnant, or currently breastfeeding during the study or within 3 months of the last dose.

Important: Always verify eligibility with the trial site directly before applying.