NCT02159716

Who might be able to join this trial:

• You have been diagnosed with one of the following cancers, confirmed by a tissue sample (biopsy): pancreatic cancer that has spread to other parts of the body; ovarian cancer or a related abdominal cancer that has come back or not gone away; or a type of lung lining cancer called epithelial malignant pleural mesothelioma.
• Your cancer has continued or come back after trying at least one standard chemotherapy treatment.
• Your cancer can be measured on a scan using standard methods.
• You are older than 18 years of age.
• You are generally able to carry out daily activities with little to no limitation (confirm with trial site for exact fitness level required).
• Doctors expect you to live for more than 3 months.
• Your blood counts, kidney, liver, and heart are working well enough to meet specific levels set by the trial (confirm with trial site for exact values).
• Your blood clotting is within an acceptable range, or you are on stable blood-thinning medication for a clot related to your cancer (confirm with trial site).
• You are willing and able to understand and sign a written consent form.
• If you are able to have children, you agree to use an approved form of contraception during the study and for 6 months after receiving the treatment cells.

Who may not be able to join:

• You have a type of mesothelioma called sarcomatoid or biphasic, as these types do not respond to this treatment.
• You have taken part in another clinical trial using an experimental drug within the last 28 days, or you plan to use another experimental drug during this trial.
• You are expected to need standard chemotherapy within 2 weeks before the cell collection or treatment steps of this trial.
• You have another active cancer that is spreading or invasive, beyond the three cancers listed above (some non-invasive skin or surface cancers may still be allowed — confirm with trial site).
• You have HIV, hepatitis C (HCV), or hepatitis B (HBV).
• You have an active autoimmune disease (such as lupus, rheumatoid arthritis, or multiple sclerosis) that has required immune-suppressing medication in the past 4 weeks, with the exception of thyroid hormone replacement.
• You currently have an ongoing or active infection.
• You are planned to receive high-dose steroid medication at the same time as this trial (a low, stable dose for a breathing condition may be acceptable — confirm with trial site).
• You need extra oxygen to breathe.
• You have previously received any treatment involving gene-modified cells.
• You have previously received an experimental treatment involving a specific protein called SS1, or certain types of mouse-based antibody therapies (confirm with trial site).
• You have a known allergy to mouse proteins.
• You have a known allergy or bad reaction to any ingredients in the study treatment, including human serum albumin, DMSO, or Dextran 40.
• You have a significant fluid build-up around your heart, moderate to severe heart failure, or another heart condition that could be made worse by this treatment or make it hard to monitor certain side effects.
• You have a significant fluid build-up around your lungs or abdomen that cannot be drained using standard methods (having a drainage tube already in place before joining may be acceptable).
• You are pregnant or breastfeeding, or your pregnancy test comes back positive before starting treatment.

Important: Always verify eligibility with the trial site directly before applying.