NCT01958021

Who might be able to join this trial:

• You are a woman with advanced breast cancer (either spread to other parts of the body, or returned in the local area) that cannot be cured.
• You have gone through menopause — either naturally (based on age or periods stopping for 12+ months), or because you had both ovaries surgically removed.
• You have not yet received any systemic (whole-body) treatment, such as chemotherapy or hormone therapy, for your advanced breast cancer.
• Your breast cancer has been confirmed by a lab test to be estrogen-receptor positive and/or progesterone-receptor positive.
• Your breast cancer has been confirmed by a lab test to be HER2-negative.
• You have at least one area of cancer that can be measured on a scan, or at least one bone lesion of a specific type (confirm with trial site).
• Your general health and ability to carry out daily activities is rated at a good level (ECOG score of 0 or 1 — confirm with trial site).

Who may not be able to join:

• You have previously taken a CDK4/6 inhibitor medication (confirm with trial site for examples).
• You have already received systemic treatment (such as chemotherapy or hormone therapy) for your advanced breast cancer — though short-term use of certain hormone therapies (14 days or less) may be allowed (confirm with trial site).
• You are currently taking another anti-cancer treatment at the same time.
• You have had another cancer within the past 3 years, with some exceptions such as certain treated skin cancers or cervical cancer that was fully removed.
• You have active heart problems or a significant history of heart issues, including heart attacks, heart failure, irregular heartbeats, cardiomyopathy, low heart pumping function, or abnormal heart readings on a screening test.
• Your blood pressure at screening is too high (above 160) or too low (below 90) (confirm with trial site for units).
• You are currently taking certain medications that cannot be stopped at least 7 days before starting the trial, including some that affect how the body processes drugs, affect heart rhythm, or include herbal supplements (confirm with trial site for specific medications).

Important: Always verify eligibility with the trial site directly before applying.