NCT01951482

Who might be able to join this trial:

• You have been diagnosed with a specific type of lung cancer called non-squamous non-small cell lung cancer (NSCLC), confirmed by a lab test, and your cancer does not have certain genetic features (EGFR wild type and ALK negative)
• You have brain tumors (metastases) confirmed by MRI — either 3 or more brain tumors, or 1–2 brain tumors that cannot be treated locally or where you prefer not to have local treatment — and at least one brain tumor is larger than 5 mm
• You are between 18 and 75 years old
• You are generally in good physical health and able to carry out daily activities (confirm with trial site what fitness level is required)
• Your blood counts, liver, and kidney function are within acceptable ranges as measured by blood and urine tests
• Doctors expect you to live for at least 12 weeks
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before joining and agree to use contraception during the trial and for 8 weeks after your last dose; if you are a man, you must agree to use contraception during the trial and for 8 weeks after your last dose, or have had a sterilisation procedure
• You are able and willing to follow the study schedule and attend follow-up appointments
• You understand the trial and are willing to sign a consent form

Who may not be able to join:

• Your lung cancer is a mixed type that includes small cell cancer, or is mainly made up of squamous cells
• You have coughed up a significant amount of blood (at least half a teaspoon) in the month before joining the trial
• Your brain tumors are bleeding
• Scans show that your tumor has grown into or is surrounding major blood vessels
• You had major surgery (such as chest surgery) or a serious injury in the 28 days before joining, or are expected to need major surgery during the trial
• You had a minor surgical procedure within 48 hours before starting the study treatment (with some exceptions — confirm with trial site)
• You are currently taking high-dose aspirin (over 325 mg per day) or certain anti-inflammatory painkillers that affect blood clotting
• You are currently taking full-dose blood thinners or clot-dissolving medications by mouth or injection (preventive low-dose use for certain catheters may be allowed — confirm with trial site)
• You have a known tendency to bleed or a blood clotting disorder
• Your blood pressure is not controlled and is too high (above 150/100 mmHg)
• You have previously had a severe high blood pressure crisis or high blood pressure affecting the brain
• You have significant heart or blood vessel problems, such as a recent stroke, heart attack within the last 6 months, unstable chest pain, moderate-to-severe heart failure, or serious irregular heartbeat
• You have had significant blood vessel disease or a blood clot in the 6 months before joining the trial
• You have a wound that is not healing, an active stomach ulcer, or a broken bone that has not healed
• You have had a hole in the bowel, an abdominal fistula (abnormal connection in the abdomen), or an abdominal abscess in the 6 months before joining
• You are a woman with a uterus who is not using effective contraception during the study and for 6 months after the last dose, or a man who does not agree to use contraception
• You are pregnant or breastfeeding
• You have taken part in another clinical trial or received an experimental treatment within 28 days before joining
• You are known to be allergic to the study drug (bevacizumab) or any of the chemotherapy drugs used in the trial
• You have an active infection currently requiring antibiotic treatment through a drip, or another serious medical condition that could make treatment risky
• You have been diagnosed with a fistula (abnormal connection) between your airway and food pipe
• You have been diagnosed with another cancer in the past 5 years, with some exceptions such as fully treated skin cancer, cervical cancer, localised prostate cancer, or breast cancer in specific circumstances (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.