NCT01737502

Who might be able to join this trial:

• You have been diagnosed with lung cancer (specifically squamous cell, a type called RAS-mutated adenocarcinoma, or small cell lung cancer), confirmed by a tissue or cell sample test
• You have already received at least one round of chemotherapy that included a platinum-based drug combination, and there are no other standard treatment options available to you
• If you had previous radiation therapy, you have recovered from its side effects before joining (hair loss is the exception — that is acceptable)
• Your blood counts are at acceptable levels: enough white blood cells, platelets, and red blood cells (confirm specific numbers with trial site)
• Your liver function tests are within acceptable ranges (confirm with trial site)
• You are reasonably active and able to care for yourself to a basic degree (rated 0, 1, or 2 on a standard activity scale)
• If you are a woman who could become pregnant, you have had a negative pregnancy test within 7 days before registering
• You are able to understand and agree to the study terms
• You are expected to live at least 12 weeks or more
• You are willing to return to the enrolling Mayo Clinic location for follow-up visits
• You are willing to provide tissue samples for research purposes as part of the study

Who may not be able to join:

• You are pregnant or currently breastfeeding
• You are a man or woman capable of having children but are unwilling to use adequate birth control during the study
• You have brain or spinal cord involvement from your cancer that is causing symptoms, has not been treated, or is not well controlled; however, if your brain involvement has been treated and is stable without symptoms or need for steroids, you may still be eligible (confirm with trial site)
• You are HIV-positive and currently taking combination anti-retroviral medication
• You are unwilling or unable to follow the study requirements
• You previously received radiation to a large portion (25% or more) of your bone marrow
• You had major surgery or a significant injury within the past 4 weeks, or minor surgery within the past 2 weeks (placement of a port or IV access device does not count as surgery here)
• You have certain serious or poorly controlled health conditions, including: high blood pressure that is difficult to control or a history of not following blood pressure treatment; chest pain from heart disease; heart failure within the last 3 months (unless your heart is pumping adequately); a heart attack within the last 6 months; an irregular heartbeat; poorly controlled diabetes; serious lung scarring or inflammation; coughing up blood recently (though if this has been treated and resolved for more than 14 days, you may still be considered — confirm with trial site); significantly high triglyceride or cholesterol levels; or any other illness that the study doctor feels would make it unsafe for you to participate
• You are currently taking St. John's Wort (a herbal supplement), as it affects how the body processes certain medications
• You have another active cancer, except for certain limited exceptions such as non-melanoma skin cancer, localized prostate cancer, or early-stage cervical changes; and you must not be receiving other cancer-fighting drugs (certain hormone treatments may be allowed at the doctor's discretion — confirm with trial site)
• You are taking certain medications that strongly affect how the body breaks down drugs through a specific liver pathway, and you are unable to stop taking them (confirm specific medications with trial site)

Important: Always verify eligibility with the trial site directly before applying.