NCT01719926

Who might be able to join this trial:

• You have been diagnosed with a cancer that has been confirmed by a tissue sample (biopsy), and you are receiving certain chemotherapy treatments containing cisplatin (with gemcitabine or 5FU/capecitabine) or a combination called CAPOX (oxaliplatin and capecitabine), given in 3-week cycles.
• You are 18 years of age or older.
• You have not received platinum-based chemotherapy (a specific type of chemo) for at least 6 months before joining the trial.
• You have at least one area of cancer that doctors can measure or track.
• You are in good general health and able to carry out daily activities with little or no limitation (confirm with trial site for exact fitness level required).
• If you are a woman who could become pregnant, you must be using reliable contraception, have a negative pregnancy test, and agree not to breastfeed during the trial.
• You are willing and able to give written consent to take part.

Who may not be able to join:

• You have a known allergy or bad reaction to indomethacin, anti-nausea medications, aspirin, or similar anti-inflammatory medicines.
• You have cancer that has spread to your brain or the lining around your brain and is causing symptoms.
• You have epilepsy or seizures that require medication to control.
• You have uncontrolled high blood pressure, or a history of blood pressure that is hard to manage.
• You have unstable chest pain (angina), serious heart failure, a recent heart attack (within the last 6 months), or a serious uncontrolled irregular heartbeat.
• You have an active stomach ulcer, gastritis, or inflammatory bowel disease.
• You have a history of bleeding in your stomach or digestive system.
• You have a history of stroke or other problems with blood vessels in the brain.
• You have a condition that causes problems with blood clotting or unusual bleeding.
• Your kidneys are not working well enough (confirm with trial site for exact levels required).
• Your blood counts (white blood cells, platelets, or red blood cells) are too low (confirm with trial site for exact levels required).
• Certain liver-related blood test results are too high (confirm with trial site for exact levels required).
• You are unable or unwilling to follow the rules of the trial.
• You are regularly taking steroid medications (inhaled/nebulised steroids are allowed).
• You have had radiation therapy within 4 weeks before starting the trial.
• You have taken part in another experimental treatment within 4 weeks before starting the trial.
• You have used omega-3 or omega-6 supplements, including fish oil products, within 2 weeks before starting the trial.
• You regularly use anti-inflammatory painkillers (such as ibuprofen), aspirin, or similar medicines.
• You are currently taking blood-thinning (anticoagulant) medication.

Important: Always verify eligibility with the trial site directly before applying.