NCT01684878

Who might be able to join this trial:

• You have been diagnosed with ovarian cancer, primary peritoneal cancer, and/or fallopian tube cancer (confirmed by lab testing of tissue or cells) that has stopped responding to platinum-based chemotherapy
• Your cancer cells show low levels of a specific protein marker called HER3 (measured by a lab test)
• You have at least one area of cancer that can be tracked or measured using scans
• You are reasonably active and able to carry out daily activities (as measured by a standard health scale — confirm with trial site)
• Your heart is pumping at least 50% of its normal capacity (confirmed by a heart scan)
• If you could become pregnant, your pregnancy test must come back negative before joining
• If you could become pregnant, you must agree to use effective birth control during the trial and for at least 6 months after treatment ends

Who may not be able to join:

• Your cancer is not the type that starts in the lining of the ovary (non-epithelial tumors)
• You have a type of ovarian tumor considered "borderline" or low-risk for spreading
• You have had another type of cancer in the past 5 years that could affect your health outlook (some very minor or easily treated skin or cervical cancers may still be acceptable — confirm with trial site)
• You have previously been treated with more than 2 different chemotherapy drug combinations
• You have had radiotherapy (radiation treatment) to your pelvis or abdomen at any point in the past
• You have an uncontrolled brain or nervous system condition unrelated to your cancer, such as uncontrolled seizures
• You have significant nerve damage or tingling/numbness in your hands or feet (this applies only to one specific part of the trial — confirm with trial site)
• Your liver, kidneys, or other organs are not working well enough (confirm with trial site)
• You have high blood pressure that is not controlled, or another serious heart or blood vessel condition
• You currently have HIV, or an active hepatitis B or hepatitis C infection
• You are currently taking steroid medication (such as prednisolone) at a relatively high daily dose — low-dose inhaled steroids (like an asthma inhaler) may be acceptable (confirm with trial site)
• You have taken part in any other experimental treatment trial within the past 28 days
• You were previously enrolled in Part 1 of this same trial (applies to Part 2 of the trial only)
• You are currently taking part in any other clinical trial that involves a treatment

Important: Always verify eligibility with the trial site directly before applying.