NCT01662882

Who might be able to join this trial:

If you have Alzheimer's disease (AD):

• You are Japanese, male or female, and at least 50 years old, with a formal diagnosis of probable Alzheimer's disease
• You have mild to moderate memory/thinking problems, based on a standard memory test score between 10 and 24
• Your memory and thinking problems have been slowly and gradually getting worse over at least 6 months
• You live with someone, or have someone who visits you regularly, who can give information about how your memory and thinking are doing
• You are able to sign a consent form, or have a caregiver who can sign on your behalf (you would still need to show you agree)

If you have mild cognitive impairment (MCI):

• You are Japanese, male or female, and at least 50 years old
• You or someone close to you has noticed that your memory or thinking has declined
• A doctor has rated your cognitive status at a level called "CDR 0.5," which indicates very mild impairment
• You show some signs of memory or thinking difficulties, or your thinking is only borderline normal compared to what would be expected given your past abilities
• Your memory or thinking problems do not have an obvious cause, such as a recent head injury or stroke
• Your general thinking and daily functioning are still good enough that a full diagnosis of Alzheimer's disease cannot be made
• Your ability to carry out everyday activities is mostly normal
• You have not been diagnosed with dementia
• Your score on a standard memory test is above 24
• You are seeking a first diagnosis for memory or thinking concerns, or received your first diagnosis within the past year
• You live with someone, or have someone who visits regularly, who can provide information about your thinking and memory
• You are able to sign a consent form before any study procedures take place

If you are a cognitively normal volunteer:

• You are Japanese, male or female, and at least 50 years old
• Your score on a standard memory test is 29 or higher, and you show no signs of memory or thinking problems based on history and testing
• You live with someone, or have a reliable person available, who can confirm your thinking and memory are normal
• You are able to sign a consent form before any study procedures take place

Who may not be able to join:

• You have had a diagnosis of mild cognitive impairment for more than 1 year (applies to the MCI group only)
• You have a brain or nervous system condition other than Alzheimer's disease, such as Parkinson's disease, Huntington's disease, or similar conditions
• You have been diagnosed with, or currently have, another type of dementia or brain-degenerating disease (such as Lewy body dementia)
• You have been diagnosed with a mixed type of dementia
• Your memory or thinking problems are caused by a brain injury, lack of oxygen to the brain, vitamin deficiencies, brain infection, brain tumour, significant hormone or metabolism problems, or intellectual disability (confirm with trial site)
• You have had a significant stroke or have signs of multiple small strokes that may be affecting your thinking or shown on a brain scan
• Your brain scan or other tests suggest your memory problems are caused by something other than Alzheimer's disease (or, for healthy volunteers, suggest early signs of Alzheimer's)
• You currently have a significant mental health condition, such as major depression or schizophrenia, as defined by standard medical guidelines
• You have a history of epilepsy or seizures, except for fever-related seizures in childhood
• You have significant liver, kidney, lung, metabolism, or hormone-related health problems
• You currently have significant heart or cardiovascular problems, such as a recent heart attack, unstable chest pain, uncontrolled high blood pressure, or serious heart rhythm problems (confirm with trial site for full details)
• You have used drugs or alcohol heavily in the past year, or had a prolonged history of doing so
• You have a significant infectious disease, including HIV/AIDS, or have previously tested positive for hepatitis
• You are a woman of childbearing age who is pregnant, breastfeeding, or not using reliable contraception — and you must agree to avoid pregnancy for 24 hours after receiving the study imaging agent
• In the opinion of the study doctor, you are not suitable for this type of study for any other reason
• You have had a serious allergic reaction to relevant medications in the past
• You have taken part