NCT01644825

Who might be able to join this trial:

• You have been diagnosed with ovarian cancer at stage IC, II, III, or IV, confirmed by a tissue or cell sample
• Your cancer got worse during your first round of chemotherapy, or it came back within 6 months after your last platinum-based chemotherapy treatment
• Your cancer can be measured or tracked using standard imaging or a specific blood marker (CA-125)
• You have no lasting nerve damage (such as numbness or tingling) left over from previous chemotherapy
• You are generally well enough to carry out light daily activities (confirm with trial site)
• You are between 18 and 75 years old
• Your doctors expect you to live for at least 3 more months
• You are able to swallow and keep down tablets or capsules
• You are willing and able to sign a consent form before any study procedures begin
• You are able and willing to attend all required treatment visits and follow-up appointments

Who may not be able to join:

• You have, or have previously had, another type of cancer — except for certain treated skin cancers or a very early-stage cervical condition that is being properly treated
• You have previously been treated with weekly paclitaxel chemotherapy
• You have had more than 2 previous rounds of chemotherapy
• You have a serious heart condition, including heart failure, certain heart rhythm problems, or you have had a heart attack, heart surgery, stenting, or significant heart-related events in the past 6 months
• Your blood counts are too low — specifically, your red blood cells, white blood cells, or platelets fall below certain levels (confirm exact values with trial site)
• Your kidneys are not working well enough, or your urine protein levels are too high (confirm with trial site)
• Your liver is not functioning well, based on certain blood test results being too high (confirm with trial site)
• Your blood clotting test results are higher than a certain level (confirm with trial site)
• You are pregnant, breastfeeding, or not using adequate contraception
• You are taking certain medications that cannot be stopped during the trial (confirm which medications with trial site)
• You have significant stomach or bowel problems that could affect how your body absorbs oral medication, such as inflammatory bowel disease, a history of bowel perforation, or signs of a bowel blockage
• You have any other serious or unstable health condition
• Your heart's electrical activity shows a specific abnormality on an ECG (a QTc interval over 480 ms)
• You have had a stroke, a blood clot in the lungs, or an untreated blood clot in a vein in the past 6 months
• You have visible blood in your urine
• You have had major surgery or a serious injury within the past 30 days
• Your blood pressure is not well controlled, with readings at or above 140/90 mmHg
• You still have side effects from previous cancer treatment that are moderate or getting worse
• You have, or are suspected to have, a condition that causes abnormal bleeding
• You are unable to travel to the trial centre due to where you live

Important: Always verify eligibility with the trial site directly before applying.