NCT01381861

Who might be able to join this trial:

• You have been diagnosed with ovarian, fallopian tube, or primary peritoneal cancer that has come back after previous treatment
• Your cancer can be measured using medical scans, with at least one clearly identifiable area of disease
• You are in good general health and able to carry out daily activities with little or no limitation (confirm with trial site for exact definition)
• You are expected to live for at least 3 months
• Any side effects from previous cancer treatments have fully cleared up
• You do not currently have an active infection that requires antibiotic treatment
• You previously received at least one chemotherapy treatment that included a platinum-based drug for your original diagnosis
• You may have received one additional chemotherapy treatment for when the cancer came back
• Any previous cancer treatments (including hormonal or immune therapies) were stopped at least 3 weeks before joining the trial (hormone replacement therapy may be continued)
• Your bone marrow, kidneys, liver, nervous system, and blood clotting are all working adequately (confirm with trial site)
• If you could become pregnant, you have had a negative pregnancy test and agree to use effective contraception

Who may not be able to join:

• You have previously been treated with the drug TRC105
• You are currently taking part in another clinical trial involving a treatment
• You have received any experimental treatment within the past 28 days
• You have serious wounds, ulcers, or bone fractures that are not healing
• You have active bleeding or a condition that puts you at high risk of bleeding
• Your cancer is growing into or around major blood vessels or through the wall of the bowel
• You have used blood-thinning or clot-dissolving medications within the past 10 days (except small amounts used to keep an IV line open)
• You have a history of blood clots in a deep vein, unless you have been adequately treated for this (in which case you may still be eligible — confirm with trial site)
• You have had a stomach ulcer or erosive gastritis in the past 6 months
• You have a known active hepatitis infection (viral or other)
• You have a history of cancer or other disease affecting the brain or central nervous system
• You have significant heart or blood vessel disease
• You have a known allergy to certain types of laboratory-produced antibodies used in this treatment (confirm with trial site for full details)
• You are pregnant or breastfeeding
• You are under 18 years of age
• You have had or are planning to have a major surgical procedure, open biopsy, or significant injury within 28 days before starting treatment
• You have had another type of cancer in the past, unless it was a non-melanoma skin cancer or another cancer that was fully treated with no signs of return in the last 3 years
• You have had uterine cancer diagnosed within the last 5 years, unless it met specific low-risk criteria (confirm with trial site)
• You have received chemotherapy for any other abdominal or pelvic cancer within the last 5 years (previous breast cancer chemotherapy may be acceptable if finished more than 3 years ago with no recurrence — confirm with trial site)
• You have previously had radiotherapy to any part of your abdomen or pelvis
• You have signs of a bowel blockage and need fluids or nutrition given through a drip

Important: Always verify eligibility with the trial site directly before applying.