NCT01194570

Who might be able to join this trial:

• You have been diagnosed with primary progressive multiple sclerosis (PPMS), confirmed using specific medical guidelines called the revised McDonald criteria
• Your level of physical disability, measured on a standard MS scale (EDSS), scores between 3 and 6.5 at the time of screening
• If your disability score is above 5.0, your MS symptoms must have started less than 15 years ago; if your score is 5.0 or higher, your symptoms must have started less than 10 years ago (confirm with trial site)
• If you are sexually active and could potentially father or become pregnant, you must be willing to use two forms of contraception during the study and for 48 weeks after your last dose

Who may not be able to join:

• You have a different type of MS, such as relapsing-remitting, secondary progressive, or progressive relapsing MS
• You are unable to have an MRI scan for any reason
• You have another known condition affecting the nervous system or brain
• You have a current infection, or a history of frequent or long-lasting infections
• You have a history of cancer of any kind, except certain minor skin cancers or cervical in-situ cancer that have been fully removed and resolved
• You have previously been treated with certain medicines that target B-cells, such as rituximab, ocrelizumab, atacicept, belimumab, or ofatumumab
• You have previously received certain other immune-affecting treatments, including alemtuzumab, cladribine, cyclophosphamide, mitoxantrone, bone marrow transplant, or several others (confirm full list with trial site)
• You have another condition that would require long-term use of steroid or immune-suppressing medicines during the study

Important: Always verify eligibility with the trial site directly before applying.