NCT01138111

Who might be able to join this trial:

• You have been found to have mild memory or thinking problems on formal tests, but do not have dementia or major difficulties with daily activities.
• You do not have any serious medical or neurological conditions that could be causing your memory or thinking problems, or that might stop you from being followed up over two years.
• You are able to read, understand, and sign a consent form agreeing to take part.
• You are 60 years of age or older.
• You have had at least 7 years of formal education.

Who may not be able to join:

• You scored below 24 on a standard memory and thinking test called the Mini Mental State Examination (MMSE) at the start of the trial.
• You scored above 0.5 on a standard scale used to measure dementia severity (called the Clinical Dementia Rating, or CDR) at the start of the trial (confirm with trial site).
• You regularly take certain medications that could negatively affect memory or thinking, such as some types of antidepressants, antipsychotics, or high doses of sleeping pills or anti-anxiety medication.
• You currently have or have previously had cancer.
• You have had a serious head injury, brain surgery, or bleeding in the brain that caused lasting brain damage.
• You have a history of serious depression, schizophrenia, or a related mental health condition.
• You are unable to have an MRI scan for any reason (for example, if you have a metal implant).
• You have signs, symptoms, or scan results suggesting a neurological condition other than mild memory problems or mild depression.
• You have had a severe allergic reaction in the past, or are considered to be at high risk of a serious allergic reaction to medications.
• You have taken part in another clinical drug trial in the 14 days before joining this study.

Important: Always verify eligibility with the trial site directly before applying.