NCT00982111

Who might be able to join this trial:

• You have been diagnosed with a specific type of non-small cell lung cancer (not the squamous type — for example, adenocarcinoma or large cell) confirmed by a lab test
• Your cancer is at Stage IV (meaning it has spread) at the time you would enter the study
• Your cancer can be measured or detected on scans (at least some disease must be measurable)
• Any side effects from previous cancer treatments (such as chemotherapy, surgery, radiation, or hormone therapy) have mostly resolved, except for hair loss
• You are well enough to carry out light activity and care for yourself (a doctor will assess this using a standard scale)
• Your liver, kidneys, and blood counts are working at adequate levels
• If you are a woman who could become pregnant, you must use a highly effective form of birth control during treatment and for 6 months afterward — the pill alone is not enough and must be combined with a barrier method (such as a condom)
• If you are a man, you must use effective contraception during treatment and for 6 months afterward, unless you have had a procedure to prevent fathering children
• Women who could become pregnant must have a negative pregnancy blood test before joining

Who may not be able to join:

• You have the squamous type of non-small cell lung cancer
• You have previously been treated with certain targeted therapies, including monoclonal antibodies or treatments aimed at EGFR, VEGF, or VEGF receptors (confirm with trial site if unsure)
• You have already received chemotherapy for advanced lung cancer (though prior chemotherapy given after surgery may be acceptable if it was completed at least 1 year before joining)
• You have had major surgery or taken part in another experimental treatment study within the last 4 weeks
• You have had radiation to your chest within the last 12 weeks (radiation to bones for pain relief is generally allowed)
• You have brain metastases (cancer that has spread to the brain) that are causing symptoms or require ongoing treatment with steroids or anti-seizure medication
• You have a blockage of a major vein in your chest (superior vena cava syndrome) that makes it unsafe to receive extra fluids
• You have significant heart artery disease or uncontrolled heart failure
• You have had a heart attack within the last 6 months
• You currently have an active infection requiring antibiotics, active tuberculosis, or HIV
• You have a significant history of neurological or psychiatric conditions (such as dementia, seizures, or bipolar disorder) that could affect your ability to take part in the study
• You have moderate or severe nerve damage causing numbness, tingling, or pain (Grade 2 or higher peripheral neuropathy)
• You have significant fluid build-up in body cavities that needs to be drained repeatedly
• You have any other serious uncontrolled medical or psychological condition that, in the doctor's opinion, would prevent you from completing the study
• You have a known allergy or serious reaction to any ingredient in the study treatments
• You are currently pregnant or breastfeeding
• You have a known history of drug abuse
• You currently have another active cancer (with the exception of certain treated skin cancers or early-stage cervical changes)
• You have had a different cancer in the past, unless you have been cancer-free for at least 3 years

Important: Always verify eligibility with the trial site directly before applying.