NCT00972205

Who might be able to join this trial:

• You must be older than 18 years of age.
• You must have a confirmed diagnosis (through tissue or cell testing done at the NCI Laboratory of Pathology) of a recurrent, returning, or advanced/spread cancer of the digestive tract, breast, small cell lung, ovarian, prostate, head and neck, multiple myeloma, or non-small cell lung cancer.
• You must be reasonably active and able to care for yourself, based on a standard doctor's rating scale (confirm with trial site).
• Your doctors expect you to live for at least 3 more months.
• Your blood counts, kidney, liver, and other body functions must be within acceptable ranges as measured by blood tests (confirm with trial site for specific numbers).
• Your heart tracing (ECG/EKG) must show no major abnormalities that would make treatment unsafe, in the opinion of the lead doctor.
• You must have finished previous treatments within certain time periods before joining — for example, at least 4 weeks since chemotherapy or radiation, and longer for some specific treatments (confirm with trial site for your specific situation).
• You must not have any serious ongoing illness or infection requiring IV antibiotics.
• Your cancer must be measurable by scans or physical examination.
• You must be willing and able to sign a written consent form agreeing to take part.
• You must agree to use an effective form of birth control during the study and for 30 days after it ends.

Who may not be able to join:

• Women who are pregnant, breastfeeding, or able to become pregnant — or men who could father a child — unless they are using effective birth control such as a barrier device, birth control pill, or condom.
• People with other serious ongoing illnesses.
• People who are HIV-positive.
• People with serious active infections that need IV antibiotic treatment.
• People with significant brain or nervous system conditions, including seizures within the last 3 months, or mental health conditions that would prevent them from giving informed consent or following the study rules.
• People who are still able to benefit from surgery or radiation therapy that could extend their life, or whose cancer could still respond to a potentially curative chemotherapy that they haven't yet tried.
• People with a significant history of heart disease, heart rhythm problems requiring treatment, or other heart conditions that could make treatment unsafe.
• People with active bleeding from a stomach ulcer.
• People who have had a severe allergic reaction to paclitaxel (Taxol) or its carrier substance (cremophor), even after taking preventive medication.
• People with significant bleeding disorders.
• People who have received a solid organ transplant (such as a kidney, liver, or heart transplant).
• People who take daily medication to reduce stomach acid.

Important: Always verify eligibility with the trial site directly before applying.