NCT00825201

Who might be able to join this trial:

• You have been diagnosed with advanced cancer that is mainly located in the abdominal cavity (peritoneum), and it has gotten worse after previous cancer treatments, or no standard treatments exist for your type of cancer.
• You have previously received certain chemotherapy drugs (taxanes or chemotherapy delivered directly into the abdomen) — this is allowed, as long as the abdominal treatment did not cause scarring inside the belly.
• You have ovarian cancer with remaining cancer found during a follow-up surgery, and it has been 4–6 weeks since that surgery and you have fully recovered.
• You are well enough to carry out basic daily activities (your doctor will assess this using a standard scale scored 0–2).
• Your doctor estimates you have more than 3 months to live.
• Your blood cell counts and organ function (blood, liver, and kidney tests) are within acceptable ranges.
• You are willing to use reliable contraception (or abstain from sex) during the trial if there is any chance you could become pregnant, or if your partner could become pregnant.
• You are able to understand and sign a written consent form agreeing to take part.

Who may not be able to join:

• You have had chemotherapy or radiation therapy in the last 4 weeks (or 6 weeks for certain specific drugs), or you are still experiencing side effects from previous treatment.
• You are currently taking part in another clinical trial involving an experimental treatment.
• You have cancer that has spread to the brain.
• You have had a serious allergic reaction to drugs that are chemically similar to the study drug (nab-paclitaxel).
• You currently have an infection in your abdomen or a blockage in your bowel.
• You have significant internal abdominal scarring that would make it impossible to place a tube into the abdominal cavity.
• You already have moderate or severe nerve damage (such as numbness, tingling, or pain in hands or feet) before starting the trial.
• You have serious uncontrolled health conditions, such as an active infection, heart failure, unstable chest pain, irregular heartbeat, or a mental health or personal situation that could make it hard to follow the trial requirements.
• You are currently pregnant or breastfeeding.
• You are HIV-positive and taking combination HIV medications.
• You have a large buildup of fluid in your abdomen that needs to be regularly drained — this will be reviewed individually (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.