NCT00278343

Who might be able to join this trial:

• You have been diagnosed with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer (confirmed by lab testing) that has come back or stopped responding to initial treatment.
• You have previously been treated with a platinum-based chemotherapy drug before joining this trial.
• Your cancer can be measured on a scan, showing at least one visible area of disease, OR your cancer is detectable through a blood test called CA-125 showing elevated levels on two separate tests taken more than 2 weeks apart.
• You have received no more than one prior course of chemotherapy (first-line treatment only).
• Doctors expect you to live for more than 12 weeks.
• You are well enough to carry out basic daily activities (a doctor will assess this using a standard scale).
• Your blood counts, liver function, and kidney function all fall within acceptable levels (confirmed by blood tests).
• If you could become pregnant, you must have a negative pregnancy test before starting the trial and agree to use reliable contraception throughout.
• You are willing and able to understand and sign a consent form agreeing to take part.

Who may not be able to join:

• You have had chemotherapy, radiation therapy, or major surgery within the past 4 weeks (or 6 weeks for certain specific chemotherapy drugs), or you are still experiencing side effects from previous treatment.
• Your tumour has been classified as "borderline" or "low malignant potential" (a less aggressive type of tumour).
• You currently have a bowel blockage (bowel obstruction).
• You are currently taking part in another clinical trial or have done so within the past 30 days.
• Cancer has spread to your brain.
• You have had a serious allergic reaction to a drug that is chemically similar to the trial drug (AZD2171/cediranib maleate).
• A heart tracing test (ECG) shows a specific abnormality in your heart's electrical activity, or you have a family history of a condition called long QT syndrome.
• Urine tests on two separate occasions (at least 1 week apart) show a significant level of protein in your urine.
• You have uncontrolled high blood pressure, an active infection, serious heart problems, or a mental health or personal situation that could make it difficult to follow the trial requirements.
• You are pregnant or currently breastfeeding.
• You are HIV-positive and receiving combination antiretroviral therapy.
• A recent heart tracing test (ECG) taken within the last 14 days shows any significant abnormality.
• You have been assessed as having a severe level of heart failure (classified as Class III or IV by your doctor — Class II patients who are well controlled with treatment may still be considered with extra monitoring).
• You are currently taking certain medications that can affect your heart rhythm, as these cannot be used alongside the trial drug (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.