NCT00239538

Who might be able to join this trial:

• You must be able to read and sign a consent form agreeing to take part.
• You must have high blood pressure, with specific readings recorded at a clinic visit (diastolic pressure between 95–109 and/or systolic pressure between 140–179).
• You must also have high blood pressure confirmed by a 24-hour blood pressure monitor worn at home (diastolic of 85 or higher and/or systolic of 130 or higher).
• You must be 30 years of age or older.
• You must be able to safely stop any current blood pressure medications during the trial.
• You must have been diagnosed with type-2 diabetes, with a blood sugar control reading (HbA1c) of 10% or below.
• You must be overweight or obese, measured by BMI — at least 27 for non-Asian participants, or at least 24 for Asian participants.
• If you are female, you must have a negative pregnancy test at the start of the trial.

Who may not be able to join:

• Women who could become pregnant and are not using an acceptable form of birth control, are not surgically sterile, or are currently nursing or pregnant.
• People who work night shifts.
• Anyone whose blood pressure readings were very high (systolic 180 or above, or diastolic 110 or above) at any point during the early run-in phase of the trial.
• Anyone with a known or suspected cause of high blood pressure other than primary hypertension, or who has liver or kidney problems.
• Anyone with a fasting blood sugar level above 17 mmol/l (or 300 mg/dl) at the first clinic visit.
• Anyone with narrowing of the arteries supplying both kidneys, narrowing in the artery of a single kidney, currently on dialysis, or who has had a kidney transplant.
• Anyone with clinically significant low sodium, low potassium, or high potassium levels in their blood.
• Anyone with significant dehydration or fluid loss that has not been treated.
• Anyone diagnosed with a condition called primary aldosteronism (an adrenal gland disorder causing high blood pressure).
• Anyone with a hereditary condition called hereditary fructose intolerance.
• Anyone with a bile flow blockage disorder, such as cholestasis.
• Anyone with heart failure.
• Anyone who has had a stroke in the past six months.
• Anyone with severe narrowing of the heart's coronary arteries (confirmed by a doctor).
• Anyone who has had a heart attack, heart surgery, or unstable chest pain in the past three months.
• Anyone who has had a heart procedure (percutaneous coronary intervention/PCI) in the past three months, or has one planned during the trial.
• Anyone with ongoing serious heart rhythm problems, such as ventricular tachycardia, atrial fibrillation, or atrial flutter.
• Anyone with certain structural heart conditions, including a thickened obstructive heart muscle, aortic valve narrowing, or significant narrowing of the aortic or mitral heart valves.
• Anyone with type-1 diabetes.
• Anyone who has previously experienced swelling of the face, lips, or throat (angioedema) while taking a type of blood pressure medication called an ACE inhibitor or ARB.
• Anyone with a history of drug or alcohol dependency in the past six months.
• Anyone regularly taking medications that are known to affect blood pressure and are not permitted by the trial.
• Anyone who has taken part in another drug trial in the past month.
• Anyone with a known allergy to any ingredient in the study medication.
• Anyone currently taking corticosteroids, colestipol, or cholestyramine medications.
• Anyone with a health condition that would make it unsafe to complete the trial.
• Anyone who would be unable to follow the trial's requirements.
• Anyone who has surgery planned during the trial period.
• Anyone with a history of not taking prescribed medications as directed.

Important: Always verify eligibility with the trial site directly before applying.