NCT00064311

Who might be able to join this trial:

• You are 18 years of age or older
• You are receiving a specific type of stem cell transplant from a donor (called a "non-myeloablative allogeneic hematopoietic stem cell transplantation") (confirm with trial site)
• You are able to start preventive antifungal treatment within 48 hours of beginning your transplant preparation chemotherapy, and before starting a medication called cyclosporine
• Your liver test results are within an acceptable range (no more than 5 times the upper limit of normal for bilirubin, AST, ALT, and alkaline phosphatase)
• You are able to swallow pills or oral medication
• You have suitable veins for blood draws or intravenous access
• You are not pregnant or breastfeeding, and have a negative pregnancy test
• If you are capable of having children, you agree to use effective barrier contraception (such as condoms) during the study and for 4 weeks after (or 12 weeks after if you are male)

Who may not be able to join:

• You have already been diagnosed with a serious, deep fungal infection (based on specific medical criteria)
• You have previously had a severe allergic reaction (anaphylaxis) to a group of antifungal medicines called azoles
• You are currently taking certain medications that can affect heart rhythm (such as terfenadine, cisapride, quinidine, pimozide, or dofetilide)
• You are currently taking a medication called rifampin
• You are currently using hormonal contraceptives (such as the pill, patch, or hormonal IUD)
• You are currently taking any other antifungal treatments, including amphotericin B, other azole or triazole antifungals, or echinocandins (topical/skin antifungals are generally allowed)
• You have taken another non-approved investigational drug within the last 2 weeks
• You have another medical condition that may put you at unacceptable risk during the study

Important: Always verify eligibility with the trial site directly before applying.