NCT00043472

Who might be able to join this trial:

• You are 30 years of age or older
• You have never been diagnosed with ovarian cancer (including borderline ovarian tumors) or a related cancer called primary papillary serous carcinoma of the peritoneum
• You still have at least one ovary
• You have signed a consent form allowing your personal health information to be used
• You meet at least one of the following family history or genetic risk conditions:
  • A harmful change (mutation) in the BRCA1 or BRCA2 gene has been found in your family, and either you yourself have tested positive for it, or a close relative (parent, sibling, child, grandparent, aunt/uncle, niece/nephew) has tested positive
  • You or your close relatives (on the same side of the family) have had at least two cases of ovarian and/or breast cancer, and if breast cancer is part of this, at least one case was diagnosed before menopause (or before age 50 if menopause age is unknown)
  • You are of Ashkenazi Jewish heritage and have at least one parent/sibling/child, or two grandparents/aunts/uncles, who have had breast or ovarian cancer (with at least one breast cancer diagnosed before menopause or before age 50 if unknown)
  • You are of Ashkenazi Jewish heritage and you yourself have had breast cancer diagnosed before menopause (or before age 50 if menopause age is unknown)
  • A specialist calculation tool called BRCAPRO estimates your chance of carrying a BRCA1 or BRCA2 mutation at more than 20%, based on your family's cancer history (confirm with trial site)

Who may not be able to join:

• A close relative has a known harmful BRCA1 or BRCA2 mutation, and you have already been tested and shown not to carry that exact same mutation
• You are currently pregnant or planning to become pregnant during the study
• You are already taking part in another ovarian cancer early detection study (with one specific exception — confirm with trial site)
• You have a psychiatric or psychological condition that would prevent you from giving fully informed consent
• You currently have an untreated cancer (other than certain common skin cancers)
• You have received chemotherapy, radiation therapy, or certain targeted cancer treatments within the past month (31 days)
• You have been treated for cancer that had spread to other parts of the body within the past 5 years
• You have had surgery inside your abdomen (including keyhole/laparoscopic surgery) within the past 3 months
• You have already had both ovaries removed
• You have a medical condition that makes donating blood for research unsafe, such as a chronic infectious disease, severe anaemia, or a bleeding disorder like haemophilia

Important: Always verify eligibility with the trial site directly before applying.