NCT00006036

Who might be able to join this trial:

• You have been diagnosed with an advanced and/or spreading solid tumor that has been confirmed by a lab test, and standard treatments have stopped working or no curative treatment exists
• Your cancer must be visible and measurable on a physical exam, X-ray, or scan (not just shown by a blood marker test)
• If you previously had cancer spread to the brain, it must have been treated and been stable for at least 4 weeks with no signs of getting worse
• You are 18 years of age or older
• You are well enough to carry out daily activities (a doctor will assess this using a standard scale)
• Your blood cell counts, liver values, and kidney function are within acceptable ranges based on blood tests
• Any nerve damage or hearing problems you have are mild (confirm with trial site)
• If joining the recommended phase 2 dose part of the study: your cancer has not been treated before, is advanced or spreading, and is a type where platinum-based chemotherapy is typically used (such as certain lung, ovarian, or head and neck cancers)
• If joining the recommended phase 2 dose part of the study: you have at least one tumor that can be measured by scan or physical exam

Who may not be able to join:

• You have untreated cancer that has spread to the brain or the lining around the brain
• You have had more than one prior chemotherapy treatment regimen (with some exceptions — confirm with trial site)
• You have received a total dose of cisplatin (a specific chemotherapy drug) higher than a certain level in the past
• You have previously had high-dose chemotherapy requiring a bone marrow or stem cell transplant within the last year
• You have had radiation to a large portion of your bone marrow
• You have had another cancer in the past 5 years, unless it was a treated skin cancer or cervical cancer (for the recommended phase 2 dose portion)
• You have an active or uncontrolled infection
• You have another serious illness or medical condition that could interfere with taking part in the study
• You have a known allergy to the study drug or drugs chemically similar to it
• You are currently pregnant or breastfeeding
• You are able to have children but are not willing to use effective birth control during the study
• You have received other experimental treatments or anticancer therapies within the last 4 weeks
• You are currently receiving any other experimental or anticancer treatment

Important: Always verify eligibility with the trial site directly before applying.