NCT00004696

Who might be able to join this trial:

• Babies who are scheduled to have surgery and will stay in the hospital afterward
• Babies who were born at 35 weeks of pregnancy or later
• Babies in Part I of the study who are less than 12 months old and are having a major chest, stomach, or heart operation
• Babies in Part II of the study who are less than 3 months old and are having a chest operation through the side of the body (thoracotomy)
• Babies in Part II who have a type of heart condition present at birth where the heart doesn't get enough oxygen (cyanotic congenital heart disease) and need a specific type of shunt surgery, OR who are having chest surgery to fix certain heart or airway problems such as a narrowing of the main artery from the heart, a connection between the food pipe and windpipe, or a vessel near the heart that needs to be tied off
• Babies with normal liver function
• Babies with normal kidney function

Who may not be able to join:

• Babies whose mothers used opioid (narcotic) pain medications during pregnancy
• Babies in Part I who are having certain specific surgeries, including removal of a lung, reconstruction of the windpipe or airways, repair of a hole in the diaphragm, or surgery to close large openings in the abdominal wall (confirm with trial site)
• Babies in Part I who are having a liver or kidney transplant
• Babies who have a lung disease that causes too much carbon dioxide to build up in their blood
• Babies who have high blood pressure in the lungs that would make a specific breathing test in this study unsafe (confirm with trial site)
• Babies who are allergic to morphine
• Babies who have a severe developmental condition that would make it impossible to assess their pain levels

Important: Always verify eligibility with the trial site directly before applying.