NCT00004688

Who might be able to join this trial:

• You have a brain tumor that has been confirmed by a tissue sample (biopsy) and it has come back or stopped responding to treatment — specific types include glioblastoma multiforme, anaplastic astrocytoma, gliosarcoma, anaplastic oligodendroglioma, or mixed anaplastic glioma
• You have a brainstem tumor that has clearly continued to grow after initial treatment
• Your disease can be measured on scans
• You have had previous radiation therapy or surgery (these are allowed)
• It has been at least 4 weeks since your last chemotherapy treatment (or at least 6 weeks if that treatment included certain drugs called nitrosoureas or mitomycin)
• You are well enough to carry out most daily activities (based on standard doctor-assessed fitness scales)
• Your blood cell counts are at healthy enough levels — specifically, your white blood cells, platelets, and other markers are within required ranges
• Your liver and kidney function tests are within acceptable limits
• If you have a known lung condition, your lungs must still have a minimum level of breathing capacity (confirm with trial site)

Who may not be able to join:

• You have another active cancer at the same time
• You are currently pregnant or breastfeeding
• You are able to become pregnant but are unwilling to use effective birth control during the trial
• Your pregnancy test result is positive

Important: Always verify eligibility with the trial site directly before applying.